ID H2PCY7_PONAB Unreviewed; 300 AA.
AC H2PCY7; A0A2J8ULI7; A0A6D2Y6G1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 {ECO:0000256|ARBA:ARBA00015644};
DE EC=2.4.99.20 {ECO:0000256|ARBA:ARBA00012600};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
DE AltName: Full=2'-phospho-ADP-ribosyl cyclase {ECO:0000256|ARBA:ARBA00031840};
DE AltName: Full=2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase {ECO:0000256|ARBA:ARBA00030418};
DE AltName: Full=2'-phospho-cyclic-ADP-ribose transferase {ECO:0000256|ARBA:ARBA00029787};
DE AltName: Full=ADP-ribosyl cyclase 1 {ECO:0000256|ARBA:ARBA00031355};
DE AltName: Full=Cyclic ADP-ribose hydrolase 1 {ECO:0000256|ARBA:ARBA00030272};
GN Name=CD38 {ECO:0000313|Ensembl:ENSPPYP00000016333.2};
GN ORFNames=CR201_G0027072 {ECO:0000313|EMBL:PNJ46139.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000016333.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000016333.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ46139.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ46139.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000016333.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000457};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ADP-ribosyl cyclase family.
CC {ECO:0000256|ARBA:ARBA00005406}.
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DR EMBL; NDHI03003454; PNJ46139.1; -; Genomic_DNA.
DR RefSeq; XP_002814660.1; XM_002814614.3.
DR STRING; 9601.ENSPPYP00000016333; -.
DR Ensembl; ENSPPYT00000016996.3; ENSPPYP00000016333.2; ENSPPYG00000014618.3.
DR GeneID; 100457558; -.
DR KEGG; pon:100457558; -.
DR CTD; 952; -.
DR eggNOG; ENOG502S1HV; Eukaryota.
DR GeneTree; ENSGT00390000017291; -.
DR HOGENOM; CLU_067834_0_1_1; -.
DR OMA; VHDFTEK; -.
DR OrthoDB; 4265952at2759; -.
DR TreeFam; TF332530; -.
DR Proteomes; UP000001595; Chromosome 4.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:Ensembl.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR CDD; cd04759; Rib_hydrolase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR003193; ADP-ribosyl_cyclase.
DR PANTHER; PTHR10912; ADP-RIBOSYL CYCLASE; 1.
DR PANTHER; PTHR10912:SF5; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE 1; 1.
DR Pfam; PF02267; Rib_hydrolayse; 1.
DR SUPFAM; SSF52309; N-(deoxy)ribosyltransferase-like; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 300 AA; 34309 MW; 9A10598DD3BE89EB CRC64;
MANCEFSPVS GDKPCCRLSR RAQLCLGVCI LVLIVVVVVA VVVPRWRQQW SGPGTTKRFP
ETVLERCVKY TEIYPEMRHV DCQSVWDAFK GAFISKHPCN ITEEDYQPLM KLGTQTVPCN
KILLWSRIKD LAHQFTQVQR DMFTLEDTLL GYLADDLTWC GEFNTSEINY QSCPDWRKDC
SNNPVSVFWK TVSHRFAEAA CGVVHVMLNG SRSKIFDKNS TFGSVEVHNL QPEKVQTLEA
WVIHGGREDS RDLCQDPTIK ELESIISKRN IQFSCKNIYR PDKFLQCVKS PEDSSCISEI
//
