ID H2PE45_PONAB Unreviewed; 83 AA.
AC H2PE45;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Heat shock factor-binding protein 1 {ECO:0000256|ARBA:ARBA00039223};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000016754.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000016754.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000016754.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Negative regulator of the heat shock response. Negatively
CC affects HSF1 DNA-binding activity. May have a role in the suppression
CC of the activation of the stress response during the aging process.
CC {ECO:0000256|ARBA:ARBA00037689}.
CC -!- SUBUNIT: Homohexamer. Associates with heptad repeats of HSF1 trimers
CC and probably also HSF1 monomers, and with HSP70. Association with HSF1
CC trimers and HSP70 coincides with attenuation of heat shock response and
CC the conversion of HSF1 trimer to monomer.
CC {ECO:0000256|ARBA:ARBA00038772}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSBP1 family.
CC {ECO:0000256|ARBA:ARBA00006349}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2PE45; -.
DR Ensembl; ENSPPYT00000017434.2; ENSPPYP00000016754.2; ENSPPYG00000015001.2.
DR eggNOG; KOG4117; Eukaryota.
DR GeneTree; ENSGT00390000006293; -.
DR HOGENOM; CLU_149552_2_0_1; -.
DR InParanoid; H2PE45; -.
DR OMA; MNSCIGD; -.
DR TreeFam; TF314005; -.
DR Proteomes; UP000001595; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR Gene3D; 1.20.5.430; -; 1.
DR InterPro; IPR009643; HS1-bd.
DR PANTHER; PTHR19424; HEAT SHOCK FACTOR BINDING PROTEIN 1; 1.
DR PANTHER; PTHR19424:SF3; HEAT SHOCK FACTOR-BINDING PROTEIN 1; 1.
DR Pfam; PF06825; HSBP1; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
SQ SEQUENCE 83 AA; 9399 MW; 5F14E6D46A4DBDA5 CRC64;
IAETDPKTER ELTSVVQTLL KQIQDKFQTM SDQIIWRTDD MSSCIDDLEK NIADLMTQAG
VEELEGKNKI PAAQEVKVAN NLY
//
