ID   H2PEA5_PONAB            Unreviewed;       814 AA.
AC   H2PEA5; A0A2J8XPU5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=HSPA4L isoform 3 {ECO:0000313|EMBL:PNJ83948.1};
GN   Name=HSPA4L {ECO:0000313|Ensembl:ENSPPYP00000016819.3};
GN   ORFNames=CR201_G0000338 {ECO:0000313|EMBL:PNJ83948.1};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000016819.3, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000016819.3, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PNJ83948.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Susie {ECO:0000313|EMBL:PNJ83948.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA   Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA   Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA   Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA   Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPPYP00000016819.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000256|ARBA:ARBA00007381}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NDHI03003363; PNJ83948.1; -; Genomic_DNA.
DR   Ensembl; ENSPPYT00000017500.3; ENSPPYP00000016819.3; ENSPPYG00000015056.3.
DR   eggNOG; KOG0103; Eukaryota.
DR   GeneTree; ENSGT00940000158736; -.
DR   HOGENOM; CLU_005965_5_1_1; -.
DR   TreeFam; TF105043; -.
DR   Proteomes; UP000001595; Chromosome 4.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 2.
DR   Gene3D; 3.30.30.30; -; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR45639:SF5; HEAT SHOCK 70 KDA PROTEIN 4L; 1.
DR   PANTHER; PTHR45639; HSC70CB, ISOFORM G-RELATED; 1.
DR   Pfam; PF00012; HSP70; 2.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 2.
DR   SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT   REGION          477..541
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          767..814
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        784..814
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   814 AA;  92002 MW;  E6C80D3F5FB5FD28 CRC64;
     MKPILLFMGR ACISLGSRTR AIGNAAKSQI VTNVRNTIHG FKKLHGRSFD DPIVQTERIR
     LPYELQKMPD GSAGVKVRYL EEERPFAIEQ VTGMLLAKLK ETSENALKKP VADCVISIPS
     FFTDAERRSV MAAAQVAGLN CLRLMNETTA VALAYGIYKQ DLPQLDEKPR NVVFIDMGHS
     AYQVSVCAFN KGKLKVLATT FDPYLGGRNF DEALVDYFCD EFKTKYKINV KENSRALLRL
     YQECEKLKKL MSANASDLPL NIECFMNDLD VSSKMNRAQF EQLCASLLAR VEPPLKAVME
     QANLQREDIS SIEIVGGATR IPAVKEQITK FFLKDISTTL NADEAVARGC ALQCAILSPA
     FKVREFSITD LVPYSVTLRW KTSFEDGSGE CEVFCKNHPA PFSKVITFHK KEPFELEAFY
     TNLHEVPYPD ARIGSFTIQN VFPQSDGDSS KVKVKVRVNI HGIFSVASAS VIEKQNLEGD
     HSDAPMETET SFKNENKDNM DKMQVDQEEG GHQKCHPEHT PEEEIDHTGA KTKSAVSDKQ
     DRLNQTLKKG KVKSIDLPIQ SSLCRQLGQD LLNSYIENEG KMIMQDKLEK ERNDAKNAVE
     EYVYDFRDRL GTVYEKFITP EDLSKLSAVL EDTENWLYED GEDQPKQVYV DKLQELKKYG
     QPIQMKYMEH EERPKALNDL GKKIQLVMKV IEAYRNKDER YDHLDPTEME KVEKYISDAM
     SWLNSKMNAQ NKLSLTQDPV VKVSEIVAKS KELDNFCNPI IYKPKPKVEV PEDKAKANNE
     HNGPMDGPSG TETKSDSTKD NSQPTKSSGE MEVD
//