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Database: UniProt
Entry: H2PF80_PONAB
LinkDB: H2PF80_PONAB
Original site: H2PF80_PONAB 
ID   H2PF80_PONAB            Unreviewed;      2027 AA.
AC   H2PF80;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   05-JUN-2019, entry version 64.
DE   SubName: Full=Myosin X {ECO:0000313|Ensembl:ENSPPYP00000017154};
GN   Name=MYO10 {ECO:0000313|Ensembl:ENSPPYP00000017154};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000017154, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000017154, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000017154}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00782}.
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DR   EMBL; ABGA01166008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01166009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01166010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01166011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01166012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01166013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01166014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01166015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01166016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01166017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9601.ENSPPYP00000017154; -.
DR   Ensembl; ENSPPYT00000017849; ENSPPYP00000017154; ENSPPYG00000015356.
DR   eggNOG; KOG4229; Eukaryota.
DR   eggNOG; COG5022; LUCA.
DR   GeneTree; ENSGT00940000155469; -.
DR   InParanoid; H2PF80; -.
DR   OMA; PILRHTH; -.
DR   TreeFam; TF316834; -.
DR   Proteomes; UP000001595; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0030175; C:filopodium; IEA:Ensembl.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003774; F:motor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030507; F:spectrin binding; IEA:Ensembl.
DR   GO; GO:0022409; P:positive regulation of cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR   GO; GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13202; FERM_C_MyoX; 1.
DR   CDD; cd14873; MYSc_Myo10; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.25.40.530; -; 1.
DR   Gene3D; 2.30.29.30; -; 5.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR031971; MYO10_CC.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR041797; MyoX_FERM_C.
DR   InterPro; IPR040640; MyoX_N_SH3.
DR   InterPro; IPR036124; MYSc_Myo10.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR038185; MyTH4_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF00612; IQ; 3.
DR   Pfam; PF16735; MYO10_CC; 1.
DR   Pfam; PF00063; Myosin_head; 1.
DR   Pfam; PF00784; MyTH4; 1.
DR   Pfam; PF00169; PH; 2.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF18597; SH3_19; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00015; IQ; 3.
DR   SMART; SM00242; MYSc; 1.
DR   SMART; SM00139; MyTH4; 1.
DR   SMART; SM00233; PH; 2.
DR   SUPFAM; SSF47031; SSF47031; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS50096; IQ; 2.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS51016; MYTH4; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS01194079};
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS00875240};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS00874053};
KW   Myosin {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS01033784};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782,
KW   ECO:0000256|SAAS:SAAS00874078};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT   DOMAIN       64    740       Myosin motor. {ECO:0000259|PROSITE:
FT                                PS51456}.
FT   DOMAIN     1213   1353       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN     1361   1466       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN     1516   1664       MyTH4. {ECO:0000259|PROSITE:PS51016}.
FT   DOMAIN     1669   2013       FERM. {ECO:0000259|PROSITE:PS50057}.
FT   NP_BIND     158    165       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00782}.
FT   REGION      620    642       Actin-binding. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00782}.
FT   REGION      820    840       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H2PF80}.
FT   REGION      979   1103       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H2PF80}.
FT   COMPBIAS   1003   1032       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                H2PF80}.
FT   COMPBIAS   1037   1079       Polar. {ECO:0000256|MobiDB-lite:H2PF80}.
SQ   SEQUENCE   2027 AA;  233820 MW;  5C46C13953B9207E CRC64;
     IDKRFFFKGT RVWLRENGQH FPSTVNSCAE GIVVFRTDYG QVFTYKQSTI THQKVTAMHP
     TNEEGVDDMA SLTELHGGSI MYNLFQRYKR NQIYTYIGSI LASVNPYQPI AGLYEPATME
     QYSRRHLGEL PPHIFAIANE CYRCLWKRHD NQCILISGES GAGKTESTKL ILKFLSVISQ
     QSLELSLKEK TSCVERAILE SSPIMEAFGN AKTVYNNNSS RFGKFVQLNI CQKGNIQGGR
     IVDYLLEKNR VVRQNPGERN YHIFYALLAG LEHEEREEFY LSTPENYHYL NQSGCVEDKT
     ISDQESFREV ITAMDVMQFS KEEVREVSRL LAGILHLGNI EFITAGGAQV SFKTALGRSA
     ELLGLDPTQL TDALTQRSMF LRGEEILTPL NVQQAVDSRD SLAMALYACC FEWVIKKINS
     RIKGNEDFKS IGILDIFGFE NFEVNHFEQF NINYANEKLQ EYFNKHIFSL EQLEYSREGL
     VWEDIDWIDN GECLDLIEKK LGLLALINEE SHFPQATDST LLEKLHSQHA NNHFYVKPRV
     AVNNFGVKHY AGEVQYDVRG ILEKNRDTFR DDLLNLLRES RFDFIYDLFE HVSSRNNQDT
     LKCGSKHRRP TVSSQFKDSL HSLMATLSSS NPFFVRCIKP NMQKMPDQFD QAVVLNQLRY
     SGMLETVRIR KAGYAVRRPF QDFYKRYKVL MRNLALPEDI RGKCTSLLQL YDASNSEWQL
     GKTKVFLRES LEQKLEKRRE EEVTHAAMVI RAHVLGFLAR KQYRKVLYCV VIIQKNYRAF
     LLRRRFLHLK KAAVVFQKQL RGQIARRVYR QLLAEKREQE EKKKQEEEEK KKREEEERER
     ERERREAELR AQQEEEMRKQ QELEALQESQ KEAELTRELE KQKENKQVEE ILRLEKEIED
     LQRMKEQQEL SLTEASLQKL QERRDQELRR LEEEACRAAQ EFLESLNFDE IDECVRNIER
     SLSVGSEFSS ELAASACEEK PNFNFSQPYP EEEVDEGFEA DDDAFKDSPN PSEHGHSDQR
     TSGIRTSDDS SEEDPYMNDT VVPTSPSADS TVLLAPSVQD SGSLHNSSSG ESTYCMPQNA
     GDLPSPDGDY DYDQDDYEDG AITSGSSVTF SNSCGSQWSP DYRCSVGTYN SSGAYRFSSE
     GAQSSFEDSE EDFDSRFDTD DELSYRRDSV YSCVTLPYFH SFLYMKGGLM NSWKRRWCVL
     KDETFLWFRS KQEALKQGWL HKKGGGSSTL SRRNWKKRWF VLRQSKLMYF ENDSEEKLKG
     TVEVRTAKEI IDNTTKENGI DIIMADRTFH LIAESPEDAG TLDVGLIDSV CASDSPDRPN
     SFVIITANRV LHCNADTPEE MHHWITLLQR SKGDTRVEGQ EFIVRGWLHK EVKNSPKMSS
     LKLKKRWFVL THNSLDYYKS SEKNALKLGT LVLNSLCSVV PPDEKIFKET GYWNVTVYGR
     KHCYRLYTKL LNEATRWSSA IQNVTDTKAP IDTPTQQLIQ DIKENCLNSD VVEQIYKRNP
     ILRYTHHPLH SPLLPLPYGD INLNLLKDKG YTTLQDEAIK IFNSLQQLES MSDPIPIIQG
     ILQTGHDLRP LRDELYCQLI KQTNKVPHPG SVGNLYSWQI LTCLSCTFLP SRGILKYLKF
     HLKRIREQFP GTEMEKYALF TYESLKKTKC REFVPSRDEI EALIHRQEMT STVYCHGGGS
     CKITINSHTT AGEVVEKLIR GLAMEDSRNM FALFEYNGHV DKAIESRTVV ADVLAKFEKL
     AATSEVGDLP WKFYFKLYCF LDTDNVPKDS VEFAFMFEQA HEAVIHGHHP APEENLQVLA
     ALRLQYLQGD YTLHAAIPPL EEVYSLQRLK ARISQSTKTF TPCERLEKRR TSFLEGTLRR
     SFRTGSVVRQ KVEEEQMLDM WIKEEVSSAR ASIIDKWKKF QGMNQEQAMA KYMALIKEWP
     GYGSTLFDVE CKEGGFPQEL WLGVSADAVS VYKRGEGRPL EVFQYEHILS FGAPLANTYK
     IVVDERELLF ETSEVVDVAK LMKAYISMIV KKRYSTTRSA SSQGSSR
//
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