ID H2PG03_PONAB Unreviewed; 1023 AA.
AC H2PG03;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=MutS homolog 3 {ECO:0000313|Ensembl:ENSPPYP00000017440.3};
GN Name=MSH3 {ECO:0000313|Ensembl:ENSPPYP00000017440.3};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000017440.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000017440.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000017440.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
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DR AlphaFoldDB; H2PG03; -.
DR Ensembl; ENSPPYT00000018147.3; ENSPPYP00000017440.3; ENSPPYG00000015601.3.
DR eggNOG; KOG0218; Eukaryota.
DR GeneTree; ENSGT00550000074949; -.
DR InParanoid; H2PG03; -.
DR OMA; HIAPCEL; -.
DR TreeFam; TF300525; -.
DR Proteomes; UP000001595; Chromosome 5.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 856..872
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 1023 AA; 116015 MW; 75D8F6DBE54C5F20 CRC64;
MSGNSEPKKC LRTRNVLKSL EKLKEFCCDS ALPPNRVQTE SLQERFAVLP KCTDFDDISL
LHAKNAVSSE DLKCQINQKD TTLFDLSQFG SSNTSHENLQ KTASKPANKR SKSIYTPLEL
QYIEMKQQHK DAVLCVECGY KYRFFGEDAE IAARELNIYC HLDHNFMTAS IPTHRLFVHV
RRLVAKGYKV GVVKQTETAA LKAIGDNRSS LFSRKLTALY TKSTLIGEDV NPLIKLDDAV
NVDEIMTDTS TSYLLCISEN KENVRDKKKG NIFIGIVGVQ PATGEVVFDS FQDSASRSEL
ETRMSSLQPV ELLLPSALSE QTEALIHRTT SVSVQDDRIR VERMDNIYFE YSHAFQAVTE
FYAKDTVDIK GSQIISGIVN LEKPVICSLA AIIKYLKEFN LEKMLSKPEN FKQLSSKMEF
MTINGTTLRN LEILQNQTDM KTKGSLLWVL DHTKTSFGRR KLKKWVTQPL LKLREINARL
DAVSEVLHSE SSVFGQIENH LRKLPDIERG LCSIYHKKCS TQEFFLIVKT LYHLKSEFQA
IIPAVNSHIQ SDLLRTVILE IPELLSPVEH YLKILNEQAA KVGDKTELFK DLSDFPLIKK
RKDEIQGVID EIQMHLQEIR KILKNPSAQY VTVSGQEFMI EIKNSAVSCI PTDWVKVGST
KAVSRFHSPF IVENYRHLNQ LREQLVLDCS AEWLDFLEKF SEHYHSLCKA VHHLATVDCI
FSLAKVAKQG DYCRPTVQEE RKIVIKNGRH PVIDVLLGEQ DQYVPNNTDL SEDSERVMII
TGPNMGGKSS YIKQVALITI MAQIGSYVPA EEATIGIVDG IFTRMGAADN IYKGRSTFME
ELTDTAEIIR KATSQSLVIL DELGRGTSTH DGIAIAYATL EYFIRDVKSL TLFVTHYPPV
CELEKNYSHQ VGNYHMGFLV SEDASKLDPG AEEQVPDFVT FLYQITRGIA ARSYGLNVAK
LADVPGEILK KAAHKSKELE GLINTKRKRL KYFAKLWTMH NAQDLQKWTE EFEMEETQTS
LLH
//
