ID H2PG38_PONAB Unreviewed; 777 AA.
AC H2PG38; A0A2J8TD86;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=MCTP1 isoform 5 {ECO:0000313|EMBL:PNJ30963.1};
DE SubName: Full=Multiple C2 and transmembrane domain containing 1 {ECO:0000313|Ensembl:ENSPPYP00000017480.2};
GN Name=MCTP1 {ECO:0000313|Ensembl:ENSPPYP00000017480.2};
GN ORFNames=CR201_G0035914 {ECO:0000313|EMBL:PNJ30963.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000017480.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000017480.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ30963.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ30963.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000017480.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; NDHI03003507; PNJ30963.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000018188.2; ENSPPYP00000017480.2; ENSPPYG00000015636.2.
DR eggNOG; KOG1030; Eukaryota.
DR GeneTree; ENSGT00940000156031; -.
DR HOGENOM; CLU_011170_0_1_1; -.
DR TreeFam; TF323373; -.
DR Proteomes; UP000001595; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04042; C2A_MCTP_PRT; 1.
DR CDD; cd08376; C2B_MCTP_PRT; 1.
DR CDD; cd08377; C2C_MCTP_PRT; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR013583; MCTP_C.
DR PANTHER; PTHR45911; C2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45911:SF3; MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF08372; PRT_C; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00239; C2; 3.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR PROSITE; PS50004; C2; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 586..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..138
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 230..347
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 381..502
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 777 AA; 89344 MW; 75F24EC8E2C9C9D7 CRC64;
MLDSCKLKSA CNLPFICNKK INAAGTSNAE VPLADPGMYQ LDITLRRGQS LAARDRGGTS
DPYVKFKIGG KEVFRSKIIH KNLNPVWEEK ACILVDHLRE PLYIKVFDYD FGLQDDFMGS
AFLDLTQLEL NRPTDVTLTL KDPHYPDHDL GIILLSVILT PKEGESRDVT MLMRKSWKRS
SKELSENEVG GSYFSVKSLF WRTCGRPALP VLGFCRAELQ NPYCKNVQFQ TQSLRLSDLH
RKSHLWRGIV SITLIEGRDL KAMDSNGLSD PYVKFRLGHQ KYKSKIMPKT LNPQWREQFD
FHLYEERGGI IDITAWDKDA GKRDDFIGRC QVDLSALSRE QTHKLELQLE EGEGHLVLLV
TLTASATVSI SDLSVNSLED QKEREEILKR YSPLRIFHNL KDVGFLQVKV IRAEGLMAAD
VTGKSDPFCV VELNNDRLVT HTVYKNLNPE WNKVFTFNIK DIHSVLEVTV YDEDRDRSAD
FLGKVAIPLL SIQNGEQKAY VLKNKQLTGP TKGVIYLEID VIFNAVKASL RTLIPKEQKY
IEEENRLSKQ LLLRNFIRMK RCVMVLVNAA YYVNSCFDWD SPPRSLAAFV LFLFVVWNFE
LYMIPLVLLL LLTWNYFLII SGKDNRQRDT VVEDMLEDEE EEDDKDDKDS EKKGFINKIY
AIQEVCVSVQ NILDEVASFG ERIKNTFNWT VPFLSWLAIV ALCVFTVILY CIPLRYIVLV
WGINKFTKKL RSPYAIDNNE LLDFLSRVPS DVQVVQYQEL KPDPSHSPYK RKKNNLG
//
