ID H2PI49_PONAB Unreviewed; 215 AA.
AC H2PI49; A0A2J8S4T9; A0A663D7Z9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=H1.1 linker histone, cluster member {ECO:0000313|Ensembl:ENSPPYP00000018227.1};
DE SubName: Full=HIST1H1A isoform 1 {ECO:0000313|EMBL:PNJ15787.1};
GN Name=H1-1 {ECO:0000313|Ensembl:ENSPPYP00000018227.1};
GN ORFNames=CR201_G0046166 {ECO:0000313|EMBL:PNJ15787.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018227.1, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018227.1, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ15787.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ15787.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000018227.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003894}.
CC -!- SIMILARITY: Belongs to the histone H1/H5 family.
CC {ECO:0000256|RuleBase:RU003894}.
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DR EMBL; NDHI03003609; PNJ15787.1; -; Genomic_DNA.
DR RefSeq; XP_002816545.1; XM_002816499.2.
DR STRING; 9601.ENSPPYP00000018227; -.
DR Ensembl; ENSPPYT00000018952.2; ENSPPYP00000018227.1; ENSPPYG00000016298.2.
DR GeneID; 100433392; -.
DR KEGG; pon:100433392; -.
DR CTD; 3024; -.
DR eggNOG; KOG4012; Eukaryota.
DR GeneTree; ENSGT00940000163269; -.
DR HOGENOM; CLU_052897_7_0_1; -.
DR OMA; HKEEART; -.
DR OrthoDB; 5362469at2759; -.
DR TreeFam; TF313664; -.
DR Proteomes; UP000001595; Chromosome 6.
DR GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005819; H1/H5.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11467; HISTONE H1; 1.
DR PANTHER; PTHR11467:SF177; HISTONE H1.1; 1.
DR Pfam; PF00538; Linker_histone; 1.
DR PRINTS; PR00624; HISTONEH5.
DR SMART; SM00526; H15; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51504; H15; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|RuleBase:RU003894};
KW Citrullination {ECO:0000256|ARBA:ARBA00022934};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003894};
KW Nucleus {ECO:0000256|RuleBase:RU003894};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 39..112
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..215
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 215 AA; 21946 MW; 28D6C55DACFFFC8E CRC64;
MSETVPTAPA ASAAPEKPLA GKKAKKPAKA VVASKKKPAG PSVSELIVQA ASSSKERGGV
SLAALKKALA VAGYDVEKNN SRIKLGIKSL VSKGTLVQTK GTGASGSFKL NKKAFSVETK
PGASKVAAKT KATGASKKLK KATGASKKSV KTPKKAKKPA ATRKSSKNPK KPKTLKPKKV
AKSPAKAKAV KPKAAKAKVT KPKTAKPKKA APKKK
//
