ID H2PI89_PONAB Unreviewed; 130 AA.
AC H2PI89; A0A2J8SK18; A0A6D2XI81;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=Histone H2A {ECO:0000256|RuleBase:RU003767};
GN Name=LOC100456246 {ECO:0000313|Ensembl:ENSPPYP00000018282.1};
GN Synonyms=LOC100431754 {ECO:0000313|Ensembl:ENSPPYP00000026628.1},
GN LOC100433891 {ECO:0000313|Ensembl:ENSPPYP00000025066.1}, LOC100435022
GN {ECO:0000313|Ensembl:ENSPPYP00000042118.1};
GN ORFNames=CR201_G0042553 {ECO:0000313|EMBL:PNJ21119.1}, CR201_G0042559
GN {ECO:0000313|EMBL:PNJ21124.1}, CR201_G0042567
GN {ECO:0000313|EMBL:PNJ21131.1}, CR201_G0042590
GN {ECO:0000313|EMBL:PNJ21150.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018282.1, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000018282.1, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ21119.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ21119.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000018282.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC {ECO:0000256|ARBA:ARBA00002001}.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA. {ECO:0000256|ARBA:ARBA00011538, ECO:0000256|RuleBase:RU003767}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU003767}.
CC -!- SIMILARITY: Belongs to the histone H2A family.
CC {ECO:0000256|ARBA:ARBA00010691, ECO:0000256|RuleBase:RU003767}.
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DR EMBL; NDHI03003564; PNJ21119.1; -; Genomic_DNA.
DR EMBL; NDHI03003564; PNJ21124.1; -; Genomic_DNA.
DR EMBL; NDHI03003564; PNJ21131.1; -; Genomic_DNA.
DR EMBL; NDHI03003564; PNJ21150.1; -; Genomic_DNA.
DR RefSeq; XP_002816596.1; XM_002816550.2.
DR RefSeq; XP_002816616.1; XM_002816570.2.
DR RefSeq; XP_002816621.1; XM_002816575.3.
DR RefSeq; XP_002816624.1; XM_002816578.2.
DR STRING; 9601.ENSPPYP00000018268; -.
DR Ensembl; ENSPPYT00000019010.2; ENSPPYP00000018282.1; ENSPPYG00000030465.1.
DR Ensembl; ENSPPYT00000048315.1; ENSPPYP00000026628.1; ENSPPYG00000032689.1.
DR Ensembl; ENSPPYT00000050311.1; ENSPPYP00000025066.1; ENSPPYG00000035741.1.
DR Ensembl; ENSPPYT00000056607.1; ENSPPYP00000042118.1; ENSPPYG00000031055.1.
DR GeneID; 100431754; -.
DR GeneID; 100433891; -.
DR GeneID; 100435022; -.
DR KEGG; pon:100431754; -.
DR KEGG; pon:100433891; -.
DR KEGG; pon:100435022; -.
DR KEGG; pon:100456246; -.
DR eggNOG; KOG1756; Eukaryota.
DR GeneTree; ENSGT00940000153125; -.
DR HOGENOM; CLU_062828_3_1_1; -.
DR OMA; CRSHCRR; -.
DR OrthoDB; 235643at2759; -.
DR TreeFam; TF300137; -.
DR Proteomes; UP000001595; Chromosome 6.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR CDD; cd00074; H2A; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR032454; Histone_H2A_C.
DR InterPro; IPR032458; Histone_H2A_CS.
DR PANTHER; PTHR23430; HISTONE H2A; 1.
DR PANTHER; PTHR23430:SF355; HISTONE H2A.J; 1.
DR Pfam; PF00125; Histone; 1.
DR Pfam; PF16211; Histone_H2A_C; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00414; H2A; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR PROSITE; PS00046; HISTONE_H2A; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU003767};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003767};
KW Nucleosome core {ECO:0000256|ARBA:ARBA00023269,
KW ECO:0000256|RuleBase:RU003767};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU003767};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 6..89
FT /note="Histone H2A/H2B/H3"
FT /evidence="ECO:0000259|Pfam:PF00125"
FT DOMAIN 92..126
FT /note="Histone H2A C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16211"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 130 AA; 14091 MW; 48DD539793FE8256 CRC64;
MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK
TESHHKAKGK
//
