ID H2PKR7_PONAB Unreviewed; 731 AA.
AC H2PKR7; A0A2J8XAW0; A0A663DBY4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=T cell activation RhoGTPase activating protein {ECO:0000313|Ensembl:ENSPPYP00000019195.2};
DE SubName: Full=TAGAP isoform 1 {ECO:0000313|EMBL:PNJ79174.1};
GN Name=TAGAP {ECO:0000313|Ensembl:ENSPPYP00000019195.2};
GN ORFNames=CR201_G0004051 {ECO:0000313|EMBL:PNJ79174.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019195.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019195.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ79174.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ79174.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000019195.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003369; PNJ79174.1; -; Genomic_DNA.
DR RefSeq; XP_002817578.1; XM_002817532.2.
DR STRING; 9601.ENSPPYP00000019195; -.
DR Ensembl; ENSPPYT00000019951.3; ENSPPYP00000019195.2; ENSPPYG00000017141.3.
DR GeneID; 100460992; -.
DR KEGG; pon:100460992; -.
DR CTD; 117289; -.
DR eggNOG; KOG4724; Eukaryota.
DR GeneTree; ENSGT00940000157993; -.
DR HOGENOM; CLU_014209_1_0_1; -.
DR OMA; NTKPEFN; -.
DR OrthoDB; 2964977at2759; -.
DR TreeFam; TF331062; -.
DR Proteomes; UP000001595; Chromosome 6.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR PANTHER; PTHR23179:SF26; T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 88..277
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 288..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 639..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 731 AA; 80661 MW; BABFBB329AB5B5C8 CRC64;
MKLRSSHNAS KTLNANNMET LIECQSEGDI KEHPLLVTCE SEDSICQLIE VKKRKKVLSW
PFLMRRLSPA SDFSGALETD LKASLFDQPL SIICGDSDTL PRPIQDILTI LCLKGPSTEG
IFRRAANEKA RKELKEELNS GDVVDLERLP VHLLAVVFKD FLRSIPRKLL SSDLFEEWMG
ALEMQDEEDR IEALKQVADK LPRPNLLLLK HLVYVLHLIS KNSEVNRMDS SNLAICIGPN
MLTLENDQSL SFEAQKDLNN KVKTLVEFLI DNCFEIFGEN IPVHSSITSD DSLEHTDGSD
VSTLQNDSAY DSNDPDVESN SSSGISSPSR QPQVPTATAA GLDSEGPQDA QEVSPEPIVS
TVARLKNSLA QPDRRYSEPS MPSSQECLES RVTNQTLTKS EGDFPVPRVG SHLESEEAED
PFPEEVFPAV QGKTKRPVDL KIKNLAPGSV LPRALVLKAF SSSSLDASSD SSPVASPSSP
KRNFFSRHQS FTTKTEKGKP SREIKKHSMS FSFAPHKKVL TKNLSAGSGK SQDFTRDHVP
RGVRKESQLA GRIVQENGSE THNQTARGFC LRPHALSVDD VFQGADWERP GSPPSYEEAM
QGPAARLAAY GSQTVGSMTV GSMRARMLQA DCLLPPLPPA HHVEDSRHRG SKEPLPGHGL
SPLPERWKQS RTVHTSGDSL GHVSGPGRPE LPPLRTVSES VQRSKRDCLV RRCSQPVFEA
DQFQYAKESY I
//
