ID H2PQ16_PONAB Unreviewed; 1149 AA.
AC H2PQ16;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Potassium calcium-activated channel subfamily U member 1 {ECO:0000313|Ensembl:ENSPPYP00000020746.2};
GN Name=KCNU1 {ECO:0000313|Ensembl:ENSPPYP00000020746.2};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000020746.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000020746.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000020746.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; H2PQ16; -.
DR Ensembl; ENSPPYT00000021578.2; ENSPPYP00000020746.2; ENSPPYG00000018507.2.
DR eggNOG; KOG1420; Eukaryota.
DR GeneTree; ENSGT00940000161817; -.
DR HOGENOM; CLU_006846_0_0_1; -.
DR InParanoid; H2PQ16; -.
DR OMA; AWNQSRT; -.
DR TreeFam; TF314283; -.
DR Proteomes; UP000001595; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:Ensembl.
DR GO; GO:0022414; P:reproductive process; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR048735; Slowpoke-like_C.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF23; POTASSIUM CHANNEL SUBFAMILY U MEMBER 1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 23..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..322
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 470..557
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 919..1037
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 829..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1149 AA; 129514 MW; 74242DB147511E6B CRC64;
MFRTKQRNET WEDLPKMSCT TEIQAAFILS SFVTFFSGLI ILLIFRLIWR SVKKWQNIKG
TGIILELFTS GTIARNHVRS LHFQGQFRDR IEMLLSAQTF VGQVLVILVF VLSIGSLIIY
FINSADPVGS CSSYEDKTIP IDLVFNAFFS FYFGLRFMAA DDKIKFWLEM NSIVDIFTIP
PTFISYYLKS NWLGLRFLRA LRLLELPQIL QILRAIKTSN SVKFSKLLSI VLSTWFTAAG
FIHLVENSGD PWLKGRNSQN ISYFESIYLV MATTSTVGFG DVVAKTSLGR TFIMFFTLGS
LILFANYIPE MVDLFANKRK YTSSYEALKG KKFIVVCGNI TVDSVTAFLR NFLRHKSGEI
NTEIVFLGET PPSLELETIF KCYLAYTTFI SGSAMKWEDL RRVAVESAEA CLIIANPLCS
DSHAEDISNI MRVLSIKNYD STTRIIIQIL QSHNKVYLPK IPSWNWDTGD NIICFAELKL
GFIAQGCLVP GLCTFLTSLF VEQNKKVTPK QTWQKHFLNS MKNKILTQRL SDDFAGMSFP
EVARLCFLKM HLLLIAIEYK SLFTDGFCGL ILNPPAQVRI RKNTLGFFIA ETPKDVRRAL
FYCSVCHDDV FTPELITNCG CKSRSRQHIT VPSVKRMKKC LKGISSRVSG QDSPPRVFAS
TSSISNFTTR TLQHDVEQDS DQLDSSGMFH WCKPTSLDKV TLKRTGKSKH KFQNHIVACV
FGDAHSALMG LRNFVMPLRA SNYTRKELKD IVFIGSLDYL QREWRFLRNF PQIYILPGCA
LYSGDLHAAN IEQCSMCVVL SPPPKPSSSQ SMVDTEAIMA TLTIGSLQID SSSDPSPAVS
EETPGYTNAH NEKSNCRKVP ILTELKNPSN IHFIEQLGGL EGSLQETNLH LSTAFSTGTV
FSGSFLDSLL ATAFYNYHVL ELLQMLVTGG VSSQLEQHLD KDKVYGVADS CTTLLSGRNR
CKLGLLSLHE TILSDVNPRN TFGQLFCGSL DLFGILCVGL YRIIDEEELN PENKRFVITR
PANEFKLLPS DLVFCAIPFS TACYKRNEEF SLRKSYEIVN KASQTTETHS DTNCPPTIDS
VTETLYSPVY SYQPRTNSLS FPKQMAWNQS RTNSIVSSQI PLGDNAKNER KTSDEGVYDE
DPFAYSEPL
//
