ID H2PQW5_PONAB Unreviewed; 383 AA.
AC H2PQW5; A0A2J8UF79; A0A663D7N5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 08-NOV-2023, entry version 54.
DE SubName: Full=NIPA like domain containing 2 {ECO:0000313|Ensembl:ENSPPYP00000021062.2};
DE SubName: Full=NIPAL2 isoform 2 {ECO:0000313|EMBL:PNJ43909.1};
GN Name=NIPAL2 {ECO:0000313|Ensembl:ENSPPYP00000021062.2};
GN ORFNames=CR201_G0028160 {ECO:0000313|EMBL:PNJ43909.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000021062.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000021062.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ43909.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ43909.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000021062.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NIPA family.
CC {ECO:0000256|ARBA:ARBA00007230}.
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DR EMBL; NDHI03003459; PNJ43909.1; -; Genomic_DNA.
DR RefSeq; XP_002819363.2; XM_002819317.3.
DR STRING; 9601.ENSPPYP00000021062; -.
DR Ensembl; ENSPPYT00000021905.3; ENSPPYP00000021062.2; ENSPPYG00000018778.3.
DR GeneID; 100449166; -.
DR KEGG; pon:100449166; -.
DR CTD; 79815; -.
DR eggNOG; KOG2922; Eukaryota.
DR GeneTree; ENSGT00940000159321; -.
DR HOGENOM; CLU_012349_2_0_1; -.
DR OMA; LYFHKRR; -.
DR OrthoDB; 2906343at2759; -.
DR TreeFam; TF313214; -.
DR Proteomes; UP000001595; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570:SF16; NIPA-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 352..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 383 AA; 42262 MW; 2D962D6AE1D3E8E1 CRC64;
MAALAPAGPG DAALAALDEL SLNFTYRAPG AGNGSLSGDW YRRNQIHLFG VLLAILGNLV
ISVSLNIQKY SHLQLAQQEH PRPYFKSVLW WGGVLLMAVG EMGNFAAYGF APITLIAPLG
CVSVTGSAII SVTFLKDNLR ASDLLGTTLA FAGTYLLVNF APNITQAISA RTVQYYLVGW
QFLIYVILEI LIFCILLYLY KRKGMKHMVI LLTLVAILAS LTVISVKAVS GMITFSMMDK
MQLTYPIFYI MFIIMIASCV FQVKFLNQAT KLYNTTTVVP VNHIFFTISA MIAGIIFYQE
FLGAAFLTVF IYLFGCFLSF LGVFLVTRNR EKEHLQQSYI DFGNIPGKQM LDKIQPDSNS
LSYGTLPDGS DSTKSQSGEK KEV
//