ID   H2PS48_PONAB            Unreviewed;       681 AA.
AC   H2PS48; A0A2J8XI27;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=Tetratricopeptide repeat protein 39B {ECO:0000256|ARBA:ARBA00015483};
GN   Name=TTC39B {ECO:0000313|Ensembl:ENSPPYP00000021514.3};
GN   ORFNames=CR201_G0001786 {ECO:0000313|EMBL:PNJ81690.1};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000021514.3, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000021514.3, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PNJ81690.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Susie {ECO:0000313|EMBL:PNJ81690.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA   Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA   Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA   Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA   Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPPYP00000021514.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TTC39 family.
CC       {ECO:0000256|ARBA:ARBA00006400}.
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DR   EMBL; NDHI03003365; PNJ81690.1; -; Genomic_DNA.
DR   Ensembl; ENSPPYT00000022390.3; ENSPPYP00000021514.3; ENSPPYG00000019208.3.
DR   eggNOG; KOG3783; Eukaryota.
DR   GeneTree; ENSGT00950000182917; -.
DR   HOGENOM; CLU_010086_3_0_1; -.
DR   OMA; CHRFRKR; -.
DR   OrthoDB; 5477282at2759; -.
DR   TreeFam; TF313761; -.
DR   Proteomes; UP000001595; Chromosome 9.
DR   GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0010887; P:negative regulation of cholesterol storage; IEA:Ensembl.
DR   GO; GO:0010874; P:regulation of cholesterol efflux; IEA:Ensembl.
DR   GO; GO:0090181; P:regulation of cholesterol metabolic process; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR31859; TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER; 1.
DR   PANTHER; PTHR31859:SF4; TETRATRICOPEPTIDE REPEAT PROTEIN 39B; 1.
DR   Pfam; PF10300; Iml2-TPR_39; 1.
DR   Pfam; PF13174; TPR_6; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ   SEQUENCE   681 AA;  76950 MW;  BC022B527F58AA36 CRC64;
     MEAVLACRLQ GRGNRVAALR PRPRPGGSAG PSPFSLCAGL SPEPREGVGS EFFAWFLGGS
     SHRRNMALLG SRAELEADED VFEDALETIS ISSHSDMATS SLHFASCDTQ QAPRQRGAST
     VSSSSSTKVD LKSGLEECAV ALNLFLSNKF TDALELLRPW AKESMYHALG YSTIVVLQAV
     LTFEQQDIQN GISAMKDALQ TCQKYRKKYT VVESFSSLLS RGSLEQLSEE EMHAEICYAE
     CLLQKAALTF VQDENMINFI KGGLKIRTSY QIYKECLSIL HEIQKNKLQQ EFFYEFEGGV
     KLGTGAFNLM LSLLPARIIR LLEFIGFSGN RELGLLQLRE GASGRSMRSA LCCLTILAFH
     TYISLILGTG EVNVAEAERL LAPFLQQFPN GSLVLFYHAR IELLKGNLEE AQEVFRKCVS
     VQEEWKQFHH LCYWELMWIN VFQQNWMQAY YYSDLLCKES KWSKATYVFL KAAILSMLPE
     EDVVATNENV VTLFRQVDSL KQRIAGKSIP TEKFAVRKAR RYSASLPAPV KLILPALEMM
     YVWNGFSIVS KRKDLSENLL VTVEKAEAAL QSQNFNSFSV DDECLVKLLK GCCLKNLQRP
     LQAELCYSHV VESEKLLKYD HYLVPFTLFE LASLYKSQGK TDKAIKFLET ARNNYKDYSL
     ESRLHFRIQA ALHLWRKPSS D
//