ID H2PS91_PONAB Unreviewed; 718 AA.
AC H2PS91; A0A2J8XHL6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Transcription factor RFX3 {ECO:0000256|ARBA:ARBA00040859};
DE AltName: Full=Regulatory factor X 3 {ECO:0000256|ARBA:ARBA00042137};
GN Name=RFX3 {ECO:0000313|Ensembl:ENSPPYP00000021559.2};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000021559.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000021559.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000021559.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; H2PS91; -.
DR STRING; 9601.ENSPPYP00000021559; -.
DR Ensembl; ENSPPYT00000022441.2; ENSPPYP00000021559.2; ENSPPYG00000019253.3.
DR eggNOG; KOG3712; Eukaryota.
DR GeneTree; ENSGT01050000244879; -.
DR InParanoid; H2PS91; -.
DR TreeFam; TF321340; -.
DR Proteomes; UP000001595; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR039779; RFX-like.
DR InterPro; IPR007668; RFX1_trans_act.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR PANTHER; PTHR12619:SF20; TRANSCRIPTION FACTOR RFX3; 1.
DR Pfam; PF04589; RFX1_trans_act; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..718
FT /note="Transcription factor RFX3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035222379"
FT DOMAIN 152..227
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000259|PROSITE:PS51526"
FT REGION 632..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 80460 MW; 6A8E4943A8E98866 CRC64;
MISLSILLVQ QVQTVQQVQH VYPAQVQYVE GSDTVYTNGA IRTTTYPYTE TQMYSQNTGG
NYFDTQGSSA QVTTVVSSHS MVGTGGIQMG VTGGQLISSS GGTYLIGNSM ENSGHSVTHT
TRASPATIEM AIETLQKSDG LSTHRSSLLN SHLQWLLDNY ETAEGVSLPR STLYNHYLRH
CQEHKLDPVN AASFGKLIRS IFMGLRTRRL GTRGNSKYHY YGIRVKPDSP LNRLQEDMQY
MAMRQQPMQQ KQRYKPMQKV DGVADGFTGS GQQTGTSVEQ TVIAQSQHHQ QFLDASRALP
EFGEVEISSL PDGTTFEDIK SLQSLYREHC EAILDVVVNL QFSLIEKLWQ TFWRYSPSTP
TDGTTITESS NLSEIESRLP KAKLITLCKH ESILKWMCNC DHGMYQALVE ILIPDVLRPI
PSALTQAIRN FAKSLEGWLS NAMNNIPQRM IQTKVAAVSA FAQTLRRYTS LNHLAQAARA
VLQNTSQINQ MLNDLNRVDF ANVQEQASWV CQCDDNMVQR LETDFKMTLQ QQSTLEQWAA
WLDNVMMQAL KPYEGRPSFP KAARQFLLKW SFYSSMVIRD LTLRSAASFG SFHLIRLLYD
EYMFYLVEHR VAQATGETPI AVMGEFGDLN AMSPGNLDKD EGSEVESEMD EELDDSSEPQ
AKREKTELSQ AFPVGCMQPV LETGVQPSLL NPIHSEHIVT STQTIRQCSA TGNTYTAV
//
