ID H2PT75_PONAB Unreviewed; 1341 AA.
AC H2PT75; A0A2J8WRJ6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=ASTN2 isoform 3 {ECO:0000313|EMBL:PNJ72407.1};
DE SubName: Full=Astrotactin 2 {ECO:0000313|Ensembl:ENSPPYP00000021904.2};
GN Name=ASTN2 {ECO:0000313|Ensembl:ENSPPYP00000021904.2};
GN ORFNames=CR201_G0007949 {ECO:0000313|EMBL:PNJ72407.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000021904.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000021904.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ72407.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ72407.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000021904.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003380; PNJ72407.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000021904; -.
DR Ensembl; ENSPPYT00000022804.2; ENSPPYP00000021904.2; ENSPPYG00000019546.3.
DR eggNOG; ENOG502R4QT; Eukaryota.
DR GeneTree; ENSGT00390000003140; -.
DR HOGENOM; CLU_006316_1_0_1; -.
DR OMA; CHEGFAP; -.
DR OrthoDB; 4157619at2759; -.
DR TreeFam; TF332034; -.
DR Proteomes; UP000001595; Chromosome 9.
DR GO; GO:0060187; C:cell pole; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0043533; F:inositol 1,3,4,5 tetrakisphosphate binding; IEA:Ensembl.
DR GO; GO:0048105; P:establishment of body hair planar orientation; IEA:Ensembl.
DR GO; GO:2000009; P:negative regulation of protein localization to cell surface; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:InterPro.
DR GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR040685; Annexin-like.
DR InterPro; IPR045574; ASTN1_2_Fn3.
DR InterPro; IPR045575; ASTN_1_2_N.
DR InterPro; IPR040510; ASTN_2_hairpin.
DR InterPro; IPR026995; Astrotactin.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR16592; -; 1.
DR PANTHER; PTHR16592:SF2; ASTROTACTIN-2; 1.
DR Pfam; PF18411; Annexin_2; 1.
DR Pfam; PF19743; ASTN1_2_fn3; 1.
DR Pfam; PF19441; ASTN_1_2_N; 1.
DR Pfam; PF18577; ASTN_2_hairpin; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..50
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 51..1341
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041158154"
FT TRANSMEM 206..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 853..1037
FT /note="MACPF"
FT /evidence="ECO:0000259|SMART:SM00457"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1341 AA; 148551 MW; 9596F1F3F8F5A3DB CRC64;
MAAAGARLSP GPGSGLRGRP RLRFHPGPPP LLPLLLLFLL LLPPPPPLLA GATAAASREP
DSPCRLKTVT VSTLPALRES DIGWSGARAR AGAGTGAGAA AAAAASPGSP GSAGTAAESR
LLLFVRNELP GRIAVQDDLD NTELPFFTLE MSGTAADISL VHWRQQWLEN GTLYFHVSMS
SSGQLAQATA PTLQEPSEIV EEQMHILHIS VMGGLIALLL LLLVFTVALY AQRRWQKRRR
IPQKSASTEA THEIHYIPSV LLGPQARESF RSSRLQTHNS VIGVPIRETP ILDDYDCEED
EEPPRRANHV SREDEFGSQV THTLDSLGHP GEEKVDFEKK AAAEATQETV ESLMQKFKES
FRANTPIEIG QLQPPLRSTS AGKRKRRSKS RGGISFGRAK GTSGSEADDE TQLTFYTEQY
RSRRRSKGLL KSPVNKTALT LIAVSSCILA MVCGSQMSCP LTVKVTLHVP EHFIADGSSF
VVSEGSYLDI SDWLNPAKLS LYYQINATSP WVRDLCGQRT TDACEQLCDP ETGECSCHEG
YAPDPVHRHL CVRSDWGQSE GPWPYTTLER GYDLVTGEQA PEKILRSTFS LGQGLWLPVS
KSFVVPPVEL SINPLASCKT DVLVTEDPAD VREEAMLSTY FETINDLLSS FGPVRDCSRN
NGGCTRNFKC VSDRQVDSSG CVCPEELKPM KDGSGCYDHS KGIDCSDGFN GGCEQLCLQQ
TLPLPYDATS STIFMFCGCV EEYKLAPDGK SCLMLSDVCE GPKCLKPDSK FNDTLFGEML
HGYNNRTQHV NQGQVFQMTF RENNFIKDFP QLADGLLVIP LPVEEQCRGV LSEPLPDLQL
LTGDIRYDEA MGYPMVQQWR VRSNLYRVKL STITLSAGFT NVLKILTKES SREELLSFIQ
HYGSHYIAEA LYGSELTCII HFPSKKVQQQ LWLQYQKETT ELGSKKELKS MPFITYLSGL
LTAQMLSDDQ LISGVEIRCE EKGRCPSTCH LCRRPGKEQL SPTPVLLEIN RVVPLYTLIQ
DNGTKEAFKS ALMSSYWCSG KGDVIDDWCR CDLSAFDASG LPNCSPLPQP VLRLSPTVEP
SSTVVSLEWV DVQPAIGTKV SDYILQHKKV DEYTDTDLYT GEFLSFADDL LSGLGTSCVA
AGRSHGEVPE VSIYSVIFKC LEPDGLYKFT LYAVDTRGRH SELSTVTLRT ACPLVDDNKA
EEIADKIYNL YNGYTSGKEQ QMAYNTLMEV SASMLFRVQH HYNSHYEKFG DFVWRSEDEL
GPRKAHLILR RLERVSSHCS SLLRSAYIQS RVETVPYLFC RSEELRPAGM VWYSILKDTK
ITCEEKMVSM ARNTYGESKG R
//
