ID H2PWK7_PONAB Unreviewed; 2077 AA.
AC H2PWK7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Dedicator of cytokinesis 11 {ECO:0000313|Ensembl:ENSPPYP00000023128.3};
GN Name=DOCK11 {ECO:0000313|Ensembl:ENSPPYP00000023128.3};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000023128.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000023128.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000023128.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR Ensembl; ENSPPYT00000024098.3; ENSPPYP00000023128.3; ENSPPYG00000020660.3.
DR eggNOG; KOG1997; Eukaryota.
DR GeneTree; ENSGT00940000155658; -.
DR HOGENOM; CLU_000624_1_0_1; -.
DR InParanoid; H2PWK7; -.
DR OMA; YDHYIPL; -.
DR TreeFam; TF313629; -.
DR Proteomes; UP000001595; Chromosome X.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11700; DHR2_DOCK11; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF81; DEDICATOR OF CYTOKINESIS PROTEIN 11; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 165..272
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 640..818
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1609..2036
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1226..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2077 AA; 238099 MW; 9E04AB2CF5AF6F1F CRC64;
MAEVRKFTKR LSKPGTAAEL RQSVSEAVRG SVVLEKAKVV EPLDYENVIA QRKTQIYSDP
LRDLLMFPME DISISVIGRQ RRTVQSTVPE DAEKRAQSLF VKECIKTYST DWHVVNYKYE
DFSGDFRMLP CKSLRPEKIP NHVFEIDEDC EKDEDSSSLC SQKGGVIKQG WLHKANVNST
ITVTMKVFKR RYFYLTQLPD GSYILNSYKD EKNSKESKGC IYLDACIDVV QCPKMRRHAF
ELKMLDKYSH YLAAETEQEM EEWLITLKKI IQINTDSLVQ EKKETVETAQ DDETSSQGKA
ENIMASLERS MHPELMKYGR ETEQLNKLSR GDGRQNLFSF DSEVQRLDFS GIEPDIKPFE
EKCNKRFLVN CHDLTFNILG QIGDNAKGPP TNVEPFFINL ALFDVKNNCK ISADFHIDLN
PPSVREMLWG SSTQLASDGS PKGSSPESYI HGIAESQLRY IQQGIFSVTN PHPEIFLVAR
IEKVLQGNIT HCAEPYIKNS DPVKTAQKVH RTAKQVCSRL GQYRMPFAWA ARPIFKDTQG
SLDLDGRFSP LYKQDSSKLS SEDILKLLSE YKKPEKTKLQ IIPGQLNITV ECVPVDLSNC
ITSSYVPLKP FEKNCENITV EVEEFVPEMT KYCYPFTIYK NHLYVYPLQL KYDSQKTFAK
ARNIAVCVEF RDSDESDASA LKCIYGKPAG SVFTTNAYAV VSHHNQNPEF YDEIKIELPI
HLHQKHHLLF TFYHVSCEIN TKGTTKKQDT VETPVGFAWV PLLKDGRIIT FEQQLPVSAN
LPPGYLNLND AESRKQCNVD IKWVDGAKPL LKIKSHLEST IYTQDLHVHK FFHHCQLIQS
GSKEVPGELI KYLKCLHAME IQVMIQFLPV ILMQLFRVLT NMTHEDDVPI NCTMVLLHIV
SKCHEEGLDS YLRSFIKYSF RPEKPSAPQA QLIHETLATT MIAILKQSAD FLSINKLLKY
SWFFFEIIAK SMATYLLEEN KIKLPRGQRF PETYHHVLHS LLLAIIPHVT IRYAEIPDES
RNVNYSLASF LKRCLTLMDR GFIFNLINDY ISGFSPKDPK VLAEYKFEFL QTICNHEHYI
PLNLPMAFAK PKLQRVQDSN LEYSLSDEYC KHHFLVGLLL RETSIALQDN YEIRYTAISV
IKNLLIKHAF DTRYQHKNQQ AKIAQLYLPF VGLLLENIQR LAGRDTLYSC AAMPNSASRD
EFPCGFTSPA NRGSLSTDKD TAYGSFQNGH GIKREDSRGS LIPEGATGFP DQGNTGENTR
QSSTRSSVSQ YNRLDQYEIR SLLMCYLYIV KMISEDTLLT YWNKVSPQEL INILILLEVC
LFHFRYMGKR NIARVHDAWL SKHFGIDRKS QTMPALRNRS GVMQARLQHL SSLESSFTLN
HGSTTTEADI FHQALLEGNT ATEVSLTVLD TISFFTQCFK TQLLNNDGHN PLMKKVFDIH
LAFLKNGQSE VSLKHVFASL RAFISKFPSA FFKGRVNMCA AFCYEVLKCC TSKISSTRNE
ASALLYLLMR NNFEYTKRKT FLRTHLQIII AVSQLIADVA LSGGSRFQES LFIINNFANS
DRPMKATAFP TEVKDLTKRI RTVLMATAQM KEHEKDPEML IDLQYSLAKS YASTPELRKT
WLDSMAKIHV KNGDFSEAAM CYVHVAALVA EFLHRKKLFP NGCSAFKKIT PNIDEEGAMK
EDAGMMDVHY SEEVLLELLE QCVDGLWKAE RYEIISEISK LIIPIYEKRR EFEKLTQVYR
TLHGAYTKIL EVMHTKKRLL GTFFRVAFYG QSFFEEEDGK EYIYKEPKLT GLSEISLRLV
KLYGEKFGTE NVKIIQDSDK VNAKELDPKY AHIQVTYVKP YFDDKELTER KTEFERNHNI
SRFVFEAPYT LSGKKQGCIE EQCKRRTILT TSNSFPYVKK RIPINCEQQI NLKPIDVATD
EIKDKTAELQ KLCSSTDVDM IQLQLKLQGC VSVQVNAGPL AYARAFLNDS QASKYPPKKV
SELKDMFRKF IQACSIALEL NERLIKEDQV EYHEGLKSNF RDMVKELSDI IHEQASIRIL
QEDTMHSPWM SNTLHVFCAI SGTSSDRGYG SPRYAEV
//
