ID   H2PX16_PONAB            Unreviewed;       425 AA.
AC   H2PX16;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=HSF-type DNA-binding domain-containing protein {ECO:0000259|SMART:SM00415};
GN   Name=LOC100438616 {ECO:0000313|Ensembl:ENSPPYP00000023292.2};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000023292.2, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000023292.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|ARBA:ARBA00006403,
CC       ECO:0000256|RuleBase:RU004020}.
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DR   AlphaFoldDB; H2PX16; -.
DR   Ensembl; ENSPPYT00000024267.2; ENSPPYP00000023292.2; ENSPPYG00000020808.2.
DR   eggNOG; KOG0627; Eukaryota.
DR   GeneTree; ENSGT00940000163633; -.
DR   HOGENOM; CLU_053156_1_0_1; -.
DR   InParanoid; H2PX16; -.
DR   OMA; DCHHMSQ; -.
DR   OrthoDB; 5358111at2759; -.
DR   TreeFam; TF330401; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000232; HSF_DNA-bd.
DR   InterPro; IPR027725; HSF_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR   PANTHER; PTHR10015:SF282; HEAT SHOCK TRANSCRIPTION FACTOR, X-LINKED; 1.
DR   Pfam; PF00447; HSF_DNA-bind; 1.
DR   SMART; SM00415; HSF; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT   DOMAIN          97..213
FT                   /note="HSF-type DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM00415"
FT   REGION          217..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          397..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   425 AA;  46521 MW;  738A362B835D853A CRC64;
     MPHHDVTAET RGVEGCLCLV GGHVQAEERQ EEGCLRLPTG LHGDDPSPAW DDPVSTGSPN
     FRLLTEEIAF QPLAQEASFR RPHPDGDDPP QGEDNLLSLP FPQKLWRLVS SNQFLSIWWD
     DSGACIVINQ KLFEKEILKR DVAHKVFATN SITSFFRQLN LYGFRKRRQC TFRTFTRIVS
     AKRLGSILNK LEFYCHPYFQ RDAPHLLVRM KRRVGVKSAP RHQEEDEPEA AGSCLAPADP
     EQQDHTSPNE NDQVTPQHQE PAGPNTQIRS GSAPPATPVM VPDPTVASDN APVTQPAGEW
     SEGSQAHVTL VAAVPEPAAL PFLYVPGSPT QMNSYGPVVA LPTASPSTLV MDTTGLPAPG
     VLPFCHLWVP VTLVAAGTAQ PAASMAMFPH PPALHHHCPH SHHTSQYMPA SDGPQAYPDY
     ADQST
//