ID   H2PY83_PANTR            Unreviewed;      1215 AA.
AC   H2PY83; A0A2J8KES6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=von Willebrand factor A domain containing 5B1 {ECO:0000313|Ensembl:ENSPTRP00000000492.6};
GN   Name=VWA5B1 {ECO:0000313|Ensembl:ENSPTRP00000000492.6,
GN   ECO:0000313|VGNC:VGNC:10890};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000000492.6, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000000492.6, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000000492.6}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AACZ04049530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016810832.1; XM_016955343.1.
DR   RefSeq; XP_016810835.1; XM_016955346.1.
DR   AlphaFoldDB; H2PY83; -.
DR   STRING; 9598.ENSPTRP00000000492; -.
DR   PaxDb; 9598-ENSPTRP00000000492; -.
DR   Ensembl; ENSPTRT00000000564.6; ENSPTRP00000000492.6; ENSPTRG00000000286.6.
DR   GeneID; 469202; -.
DR   KEGG; ptr:469202; -.
DR   CTD; 127731; -.
DR   VGNC; VGNC:10890; VWA5B1.
DR   eggNOG; ENOG502QVJP; Eukaryota.
DR   GeneTree; ENSGT00940000158938; -.
DR   HOGENOM; CLU_389132_0_0_1; -.
DR   InParanoid; H2PY83; -.
DR   OMA; PPMETVH; -.
DR   OrthoDB; 5393645at2759; -.
DR   TreeFam; TF329720; -.
DR   Proteomes; UP000002277; Chromosome 1.
DR   Bgee; ENSPTRG00000000286; Expressed in pituitary gland and 4 other cell types or tissues.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR46299:SF1; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B1; 1.
DR   PANTHER; PTHR46299; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B2-RELATED; 1.
DR   Pfam; PF13757; VIT_2; 1.
DR   Pfam; PF13768; VWA_3; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..1215
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015092274"
FT   DOMAIN          1..149
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          361..540
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          715..807
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          938..966
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          971..990
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1088..1110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        745..761
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        777..791
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1215 AA;  133351 MW;  1241E47F9DA09C3B CRC64;
     MPGLLNWITG AALPLTASDV TSCVSGYALG LTASLTYGNL EAQPFQGLFV YPLDECTTVI
     GFEAVIADRV VTVQIKDKAK LESGHFDASH VRSPTVTGNI LQEGVSIAPH SCTPGKVTLD
     EDLERILFVA NLGTIAPMEN VTIFISTSSE LPTLPSGAVR VLLPAVCAPT VPQFCTKSTG
     TSNQQAQGKD RHCFGAWDPG SWNKLCLATL LNTDVSNPME YEFNFQLEIR GPCLLAGVES
     PTHEIRADAA PSARSAKSII ITLANKHTFD RPVEILIHPS EPHMPHVLIE KGDMTLGEFD
     QHLKGRTDFI KGMKKKSRAE RKTEIIRKRL HKDIPHHSVI MLNFCPDLQS VQPCLRKAHG
     EFIFLIDRSS SMSGISMHRV KDAMLVALKS LLPACLFNII GFGSTFKSLF PSSQTYSEDS
     LAMACDDIQR MKADMGGTNI LSPLKWVIRQ PVHRGHPRLL FLITDGAVNN TGKVLELVRN
     HAFSTRCYSF GIGPNVCHRL VKGLASVSEG SAEFLMEGER LQPKMVKSLK KAMAPVLSDV
     TVEWIFPETT EVLVSPISAS SLFPGERLVG YGIVCDASLH VSNPRSDKRR RYSMLHSQES
     GSSVFYHSQD EGPGPEGGDC AENSGAPFIL GQAKNARLAS GDSTTKHDLN LSQRRRAYST
     NQITNHKPLP RATMASDPMP AAKRYPLRKA RLQDLTNQTS LDVQRWQIDL QPLLNSGQDL
     NQGPKLRGPG ARRPSLLPQG CQPFLPWGQE TQAWSPVRER TSDSRSPGDL EPSHHPSAFE
     TETSSDWDPP AESQERASPS RPATPAPVLG KALVKGLHDS QRLQWEVSFE LGTPGPERGG
     ARDADLWSET FHHLAARAII RDFEQLAERE GEIEQGSNRR YQVSALHTSK ACNIISKYTA
     FVPVDVSKSR YLPTVVEYPN SGAALRMLSS RALAQQWRGT SSGFGRPQTM LGEDSAPGND
     MEASPTALFS KATSPGREKH GASEGPQRSL ATNTLSSMKA SENLFGSRLN LNKSRLLTRA
     AKGFLSKPLI KAVESTSGNQ SFDYIPLVSL QLASGAFLLN EAFCEATHIP MEKLKWMSPF
     TCHRVSLTTR PSESKTPSPQ LCTSSPPRHP SYDSFSLEPL AKGKLGLEPR AVVEHTGKLW
     ATVVGLAWLE HSSASYFTEW ELVAAKANSW LEQQEVPEGR TQGTLKAAAR QLFVLLRHWD
     ENLEFNMLCY NPNYV
//