ID H2PYA4_PANTR Unreviewed; 595 AA.
AC H2PYA4; A0A2J8K418;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Heteroous nuclear ribonucleoprotein R {ECO:0000313|Ensembl:ENSPTRP00000000569.6};
GN Name=HNRNPR {ECO:0000313|Ensembl:ENSPTRP00000000569.6,
GN ECO:0000313|VGNC:VGNC:1263};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000000569.6, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000000569.6, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000000569.6}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AACZ04051011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009448741.1; XM_009450466.2.
DR AlphaFoldDB; H2PYA4; -.
DR SMR; H2PYA4; -.
DR Ensembl; ENSPTRT00000000644.6; ENSPTRP00000000569.6; ENSPTRG00000000324.7.
DR GeneID; 456615; -.
DR CTD; 10236; -.
DR VGNC; VGNC:1263; HNRNPR.
DR eggNOG; KOG0117; Eukaryota.
DR GeneTree; ENSGT00940000153511; -.
DR HOGENOM; CLU_022960_2_1_1; -.
DR OMA; GRANNMY; -.
DR OrthoDB; 3184171at2759; -.
DR TreeFam; TF314932; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000000324; Expressed in fibroblast and 22 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21067; NURR_hnRNPR; 1.
DR CDD; cd12488; RRM2_hnRNPR; 1.
DR CDD; cd12494; RRM3_hnRNPR; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR041337; hnRNP_Q_AcD.
DR InterPro; IPR006535; HnRNP_R/Q_splicing_fac.
DR InterPro; IPR034411; hnRNPR_RRM2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01648; hnRNP-R-Q; 1.
DR PANTHER; PTHR21245; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; 1.
DR PANTHER; PTHR21245:SF5; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN R; 1.
DR Pfam; PF18360; hnRNP_Q_AcD; 1.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 127..206
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 208..290
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 303..373
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 595 AA; 66980 MW; C9C67D917E7BCC44 CRC64;
MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF QTGLVAYVDL
DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG VMKTYRQREK QGSKVQESTK
GPDEAKIKVF VGKIPRDLYE DELVPLFEKA GPIWDLRLMM DPLSGQNRGY AFITFCGKEA
AQEAVKLCDS YEIRPGKHLG VCISVANNRL FVGSIPKNKT KENILEEFSK VTEGLVDVIL
YHQPDDKKKN RGFCFLEYED HKSAAQARRR LMSGKVKVWG NVVTVEWADP VEEPDPEVMA
KVKVLFVRNL ATTVTEEILE KSFSEFGKLE RVKKLKDYAF VHFEDRGAAV KAMDEMNGKE
IEGEEIEIVL AKPPDKKRKE RQAARQASRS TAYEDYYYHP PPRMPPPIRG RGRGGGRGGY
GYPPDYYGYE DYYDDYYGYD YHDYRGGYED PYYGYDDGYA VRGRGGGRGG RGAPPPPRGR
GAPPPRGRAG YSQRGAPLGP PRGSRGGRGG PAQQQRGRGS RGSRGNRGGN VGGKRKADGY
NQPDSKRRQT NNQQNWGSQP IAQQPLQQGG DYSGNYGYNN DNQEFYQDTY GQQWK
//
