ID H2PYP1_PANTR Unreviewed; 396 AA.
AC H2PYP1; A0A2J8LYH1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Smad nuclear interacting protein 1 {ECO:0000313|EMBL:JAA01273.1, ECO:0000313|Ensembl:ENSPTRP00000000966.4};
GN Name=SNIP1 {ECO:0000313|EMBL:JAA01273.1,
GN ECO:0000313|Ensembl:ENSPTRP00000000966.4, ECO:0000313|VGNC:VGNC:1559};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000000966.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000000966.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA01273.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA01273.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA40157.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA11698.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000000966.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04072155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04072156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01010065; JAA01273.1; -; mRNA.
DR EMBL; GABF01010447; JAA11698.1; -; mRNA.
DR EMBL; GABE01004582; JAA40157.1; -; mRNA.
DR RefSeq; XP_513324.2; XM_513324.5.
DR STRING; 9598.ENSPTRP00000000966; -.
DR PaxDb; 9598-ENSPTRP00000000966; -.
DR Ensembl; ENSPTRT00000001073.5; ENSPTRP00000000966.4; ENSPTRG00000000547.5.
DR GeneID; 456759; -.
DR CTD; 79753; -.
DR VGNC; VGNC:1559; SNIP1.
DR eggNOG; KOG1882; Eukaryota.
DR GeneTree; ENSGT00940000156553; -.
DR OMA; ALQFRYV; -.
DR OrthoDB; 9299at2759; -.
DR TreeFam; TF312797; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000000547; Expressed in bone marrow and 21 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; IEA:Ensembl.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0140416; F:transcription regulator inhibitor activity; IEA:Ensembl.
DR GO; GO:0035196; P:miRNA processing; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR CDD; cd22718; FHA_SNIP1; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR23308:SF53; KANADAPTIN-RELATED; 1.
DR PANTHER; PTHR23308; NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1; 1.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 281..344
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT REGION 1..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..102
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..396
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 396 AA; 45788 MW; 9EC28BAFB1444719 CRC64;
MKAVKSERER GSRRRHRDGD VVLPAGVVVK QERLSPEVAP PAHRRPDHSG GSPSPPTSEP
ARPGHRGNRA RGVSRSPPKK KNKASGRRSK SPRSKRNRSP HHSTVKVKQE REDHPRRGRE
DRQHREPSEQ EHRRARNSDR DRHRGHSHQR RTSNERPGSG QGQGRDRDTQ NLQAQEEERE
FYNARRREHR QRNDVGGGGS ESQELVPRPG GNNKEKEVPA KEKPSFELSG ALLEDTNTFR
GVVIKYSEPP EARIPKKRWR LYPFKNDEVL PVMYIHRQSA YLLGRHRRIA DIPIDHPSCS
KQHAVFQYRL VEYTRADGTV GRRVKPYIID LGSGNGTFLN NKRIEPQRYY ELKEKDVLKF
GFSSREYVLL HESSDTSEID RKDDEDEEEE EEVSDS
//
