ID H2PYQ1_PANTR Unreviewed; 280 AA.
AC H2PYQ1; A0A2J8LYJ1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Four and a half LIM domains 3 {ECO:0000313|EMBL:JAA10883.1, ECO:0000313|Ensembl:ENSPTRP00000000981.3};
GN Name=FHL3 {ECO:0000313|EMBL:JAA10883.1,
GN ECO:0000313|Ensembl:ENSPTRP00000000981.3, ECO:0000313|VGNC:VGNC:540};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000000981.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000000981.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA10883.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA10883.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA34050.1}, Skin {ECO:0000313|EMBL:JAA24353.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA11990.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000000981.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04072150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01000455; JAA10883.1; -; mRNA.
DR EMBL; GABC01000454; JAA10884.1; -; mRNA.
DR EMBL; GABF01010155; JAA11990.1; -; mRNA.
DR EMBL; GABD01008747; JAA24353.1; -; mRNA.
DR EMBL; GABE01010689; JAA34050.1; -; mRNA.
DR RefSeq; XP_003308038.1; XM_003307990.4.
DR RefSeq; XP_009452419.1; XM_009454144.2.
DR RefSeq; XP_009452422.1; XM_009454147.2.
DR RefSeq; XP_513331.2; XM_513331.6.
DR STRING; 9598.ENSPTRP00000000981; -.
DR PaxDb; 9598-ENSPTRP00000000981; -.
DR Ensembl; ENSPTRT00000001089.4; ENSPTRP00000000981.3; ENSPTRG00000000560.4.
DR GeneID; 456768; -.
DR KEGG; ptr:456768; -.
DR CTD; 2275; -.
DR VGNC; VGNC:540; FHL3.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00950000183028; -.
DR HOGENOM; CLU_001357_2_0_1; -.
DR OMA; QWHQTCF; -.
DR OrthoDB; 370973at2759; -.
DR TreeFam; TF314113; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000000560; Expressed in hindlimb stylopod muscle and 19 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001725; C:stress fiber; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR CDD; cd09423; LIM1_FHL3; 1.
DR CDD; cd09427; LIM2_FHL3; 1.
DR CDD; cd09346; LIM3_FHL; 1.
DR CDD; cd09434; LIM4_FHL3; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 5.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24205; FOUR AND A HALF LIM DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24205:SF5; FOUR AND A HALF LIM DOMAINS PROTEIN 3; 1.
DR Pfam; PF00412; LIM; 4.
DR SMART; SM00132; LIM; 4.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 5.
DR PROSITE; PS00478; LIM_DOMAIN_1; 3.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
PE 2: Evidence at transcript level;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 38..98
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 99..160
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 219..280
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
SQ SEQUENCE 280 AA; 31165 MW; D1A93C3F6031F530 CRC64;
MSESFDCAKC SESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD SRELFYEDRH
FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ CSACGETVMP GSRKLEYGGQ
TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC VPCYENKFAP RCARCSKTLT QGGVTYRDQP
WHRECLVCTG CQTPLAGQQF TSRDEDPYCV ACFGELFAPK CSSCKRPIVG LGGGKYVSFE
DRHWHHNCFS CARCSTSLVG QGFVPDGDQV LCQGCSQAGP
//
