ID H2PZS3_PANTR Unreviewed; 497 AA.
AC H2PZS3; A0A2J8JUH6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Ganglioside induced differentiation associated protein 2 {ECO:0000313|EMBL:JAA05348.1, ECO:0000313|Ensembl:ENSPTRP00000001993.4};
GN Name=GDAP2 {ECO:0000313|EMBL:JAA05348.1,
GN ECO:0000313|Ensembl:ENSPTRP00000001993.4,
GN ECO:0000313|VGNC:VGNC:52949};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000001993.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000001993.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA05348.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA05348.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA42816.1}, Skin {ECO:0000313|EMBL:JAA30712.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA18694.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000001993.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GDAP2 family.
CC {ECO:0000256|ARBA:ARBA00008355}.
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DR EMBL; AACZ04034376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01005990; JAA05348.1; -; mRNA.
DR EMBL; GABF01003451; JAA18694.1; -; mRNA.
DR EMBL; GABD01002388; JAA30712.1; -; mRNA.
DR EMBL; GABE01001923; JAA42816.1; -; mRNA.
DR RefSeq; XP_001144678.1; XM_001144678.4.
DR STRING; 9598.ENSPTRP00000001993; -.
DR PaxDb; 9598-ENSPTRP00000001993; -.
DR Ensembl; ENSPTRT00000002168.5; ENSPTRP00000001993.4; ENSPTRG00000001167.5.
DR GeneID; 457160; -.
DR KEGG; ptr:457160; -.
DR CTD; 54834; -.
DR VGNC; VGNC:52949; GDAP2.
DR eggNOG; KOG2633; Eukaryota.
DR GeneTree; ENSGT00940000156336; -.
DR HOGENOM; CLU_026877_0_0_1; -.
DR OMA; VHLFRYV; -.
DR OrthoDB; 1105329at2759; -.
DR TreeFam; TF324164; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000001167; Expressed in temporal lobe and 21 other cell types or tissues.
DR GO; GO:0032526; P:response to retinoic acid; IEA:Ensembl.
DR CDD; cd02905; Macro_GDAP2-like; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR002589; Macro_dom.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR035793; Macro_GDAP2.
DR PANTHER; PTHR11106; GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR11106:SF72; GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF01661; Macro; 1.
DR SMART; SM00506; A1pp; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF52949; Macro domain-like; 1.
DR PROSITE; PS51154; MACRO; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 43..223
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT REGION 252..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 56266 MW; 2A5D2D4CF629A57D CRC64;
MDPLGAPSQF VDVDTLPSWG DSCQDELNSS DTTAEIFQED TVRSPFLYNK DVNGKVVLWK
GDVALLNCTA IVNTSNESLT DKNPVSESIF MLAGPDLKED LQKLKGCRTG EAKLTKGFNL
AARFIIHTVG PKYKNRYRTA AESSLYSCYR NVLQLAKEQS MSSLGFCVIN SAKRGYPLED
ATHIALRTVR RFLEIHGETI EKVVFAVSDL EEGTYQKLLP LYFPRSLKEE NRSLPYLPAD
IGNAEGEPVV PERQIRISEK PGAPEDNQEE EDEGLGVDLS FIGSHAFARM EGDIDKQRKL
ILQGQLSEAA LQKQHQRNYN RWLCQARSED LSDIASLKAL YQTGVDNCGR TVMVVVGRNI
PVTLIDMDKA LLYFIHVMDH IAVKEYVLVY FHTLTSEYNH LDSDFLKKLY DVVDVKYKRN
LKAVYFVHPT FRSKVSTWFF TTFSVSGLKD KIHHVDSLHQ LFSAISPEQI DFPPFVLEYD
ARENGPYYTS YPPSPDL
//
