ID H2Q035_PANTR Unreviewed; 147 AA.
AC H2Q035; A0A2J8Q3L3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Protein S100 {ECO:0000256|RuleBase:RU361184};
DE AltName: Full=S100 calcium-binding protein {ECO:0000256|RuleBase:RU361184};
GN Name=S100A1 {ECO:0000313|VGNC:VGNC:3830};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000002282.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000002282.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000002282.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Sarcoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004369}.
CC -!- SIMILARITY: Belongs to the S-100 family.
CC {ECO:0000256|ARBA:ARBA00007323, ECO:0000256|RuleBase:RU361184}.
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DR EMBL; AC192200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2Q035; -.
DR STRING; 9598.ENSPTRP00000002282; -.
DR PaxDb; 9598-ENSPTRP00000002282; -.
DR Ensembl; ENSPTRT00000002484.4; ENSPTRP00000002282.4; ENSPTRG00000001355.6.
DR VGNC; VGNC:3830; S100A1.
DR eggNOG; ENOG502SSF0; Eukaryota.
DR GeneTree; ENSGT00940000160475; -.
DR HOGENOM; CLU_138624_2_1_1; -.
DR InParanoid; H2Q035; -.
DR OMA; ACNSFFW; -.
DR TreeFam; TF332727; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000001355; Expressed in Brodmann (1909) area 10 and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR GO; GO:0044548; F:S100 protein binding; IBA:GO_Central.
DR GO; GO:0008016; P:regulation of heart contraction; IEA:InterPro.
DR CDD; cd05025; S-100A1; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR028486; S100-A1.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR PANTHER; PTHR11639:SF134; PROTEIN S100-A1-RELATED; 1.
DR PANTHER; PTHR11639; S100 CALCIUM-BINDING PROTEIN; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM00054; EFh; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU361184};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361184};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799}.
FT DOMAIN 103..138
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 147 AA; 15838 MW; EBE3EEFFFC6019A5 CRC64;
MEEPQTKTPS AEFPPYPAQL AQPATAPAAT FAALAICPEL APTSGPGQPC TAAMGSELET
AMETLINVFH AHSGKEGDKY KLSKKELKEL LQTELSGFLD AQKDVDAVDK VMKELDENGD
GEVDFQEYVV LVAALTVACN NFFWENS
//
