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Database: UniProt
Entry: H2Q0D9_PANTR
LinkDB: H2Q0D9_PANTR
Original site: H2Q0D9_PANTR 
ID   H2Q0D9_PANTR            Unreviewed;       393 AA.
AC   H2Q0D9; A0A2J8JAA9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   18-SEP-2019, entry version 53.
DE   SubName: Full=KCNJ9 isoform 1 {ECO:0000313|EMBL:PNI19715.1};
DE   SubName: Full=Potassium voltage-gated channel subfamily J member 9 {ECO:0000313|Ensembl:ENSPTRP00000002586};
GN   Name=KCNJ9 {ECO:0000313|Ensembl:ENSPTRP00000002586,
GN   ECO:0000313|VGNC:VGNC:10678};
GN   ORFNames=CK820_G0049292 {ECO:0000313|EMBL:PNI19715.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000002586, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000002586, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000002586}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:PNI19715.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI19715.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:PNI19715.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
RA   Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
RA   Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
RA   Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
RA   Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
RA   Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AACZ04025375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; NBAG03000493; PNI19715.1; -; Genomic_DNA.
DR   RefSeq; XP_016785749.1; XM_016930260.1.
DR   RefSeq; XP_016785755.1; XM_016930266.1.
DR   RefSeq; XP_016785760.1; XM_016930271.1.
DR   RefSeq; XP_016785765.1; XM_016930276.1.
DR   RefSeq; XP_016785773.1; XM_016930284.1.
DR   SMR; H2Q0D9; -.
DR   STRING; 9598.ENSPTRP00000002586; -.
DR   PaxDb; H2Q0D9; -.
DR   Ensembl; ENSPTRT00000002815; ENSPTRP00000002586; ENSPTRG00000001538.
DR   GeneID; 469548; -.
DR   KEGG; ptr:469548; -.
DR   CTD; 3765; -.
DR   VGNC; VGNC:10678; KCNJ9.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00970000193368; -.
DR   KO; K05002; -.
DR   OMA; DYASFHQ; -.
DR   OrthoDB; 956263at2759; -.
DR   TreeFam; TF313676; -.
DR   Proteomes; UP000002277; Chromosome 1.
DR   Bgee; ENSPTRG00000001538; Expressed in 2 organ(s), highest expression level in prefrontal cortex.
DR   GO; GO:0099056; C:integral component of presynaptic membrane; IEA:Ensembl.
DR   GO; GO:0098688; C:parallel fiber to Purkinje cell synapse; IEA:Ensembl.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003276; K_chnl_inward-rec_Kir3.3.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF17; PTHR11767:SF17; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01329; KIR33CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     61     82       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    136    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       25    164       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      171    341       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION        1     23       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      360    393       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        150    150       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   393 AA;  44020 MW;  C6F79F80A37B01C9 CRC64;
     MAQENAAFSP GQEEPPRRRG RQRYVEKDGR CNVQQGNVRE TYRYLTDLFT TLVDLQWRLS
     LLFFVLAYAL TWLFFGAIWW LIAYGRGDLE HLEDTAWTPC VNNLNGFVAA FLFSIETETT
     IGYGHRVITD QCPEGIVLLL LQAILGSMVN AFMVGCMFVK ISQPNKRAAT LVFSSHAVVS
     LRDGRLCLMF RVGDLRSSHI VEASIRAKLI RSRQTLEGEF IPLHQTDLSV GFDTGDDRLF
     LVSPLVISHE IDAASPFWEA SRRALERDDF EIVVILEGMV EATGMTCQAR SSYLVDEVLW
     GHRFTSVLTL EDGFYEVDYA SFHETFEVPT PSCSARELAE AAARLDAHLY WSIPSRLDEK
     VEEEGAGEGA GGEAGADKEQ NGCLPPPESE SKV
//
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