ID H2Q0V9_PANTR Unreviewed; 187 AA.
AC H2Q0V9; A0A2J8KHP3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Troponin I type 1 (Skeletal, slow) {ECO:0000313|EMBL:JAA33978.1};
DE SubName: Full=Troponin I1, slow skeletal type {ECO:0000313|Ensembl:ENSPTRP00000003069.4};
GN Name=TNNI1 {ECO:0000313|EMBL:JAA33978.1,
GN ECO:0000313|Ensembl:ENSPTRP00000003069.4,
GN ECO:0000313|VGNC:VGNC:10430};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000003069.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000003069.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA33978.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA33978.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000003069.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin
CC filament regulatory complex which confers calcium-sensitivity to
CC striated muscle actomyosin ATPase activity.
CC {ECO:0000256|ARBA:ARBA00001988}.
CC -!- SIMILARITY: Belongs to the troponin I family.
CC {ECO:0000256|ARBA:ARBA00009930}.
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DR EMBL; AACZ04071407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABE01010761; JAA33978.1; -; mRNA.
DR EMBL; GABE01010760; JAA33979.1; -; mRNA.
DR RefSeq; XP_009438902.1; XM_009440627.2.
DR STRING; 9598.ENSPTRP00000003069; -.
DR PaxDb; 9598-ENSPTRP00000003069; -.
DR Ensembl; ENSPTRT00000003333.5; ENSPTRP00000003069.4; ENSPTRG00000001834.6.
DR KEGG; ptr:469636; -.
DR VGNC; VGNC:10430; TNNI1.
DR eggNOG; KOG3977; Eukaryota.
DR GeneTree; ENSGT01030000234588; -.
DR HOGENOM; CLU_098686_1_0_1; -.
DR OMA; CIHNTRE; -.
DR OrthoDB; 2882372at2759; -.
DR TreeFam; TF313374; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000001834; Expressed in hindlimb stylopod muscle and 10 other cell types or tissues.
DR GO; GO:0005861; C:troponin complex; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0060048; P:cardiac muscle contraction; IBA:GO_Central.
DR GO; GO:0003009; P:skeletal muscle contraction; IBA:GO_Central.
DR GO; GO:0014883; P:transition between fast and slow fiber; IEA:Ensembl.
DR GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR Gene3D; 1.20.5.350; -; 1.
DR Gene3D; 6.10.250.180; -; 1.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR13738; TROPONIN I; 1.
DR PANTHER; PTHR13738:SF9; TROPONIN I, SLOW SKELETAL MUSCLE; 1.
DR Pfam; PF00992; Troponin; 1.
DR SUPFAM; SSF90250; Troponin coil-coiled subunits; 1.
PE 2: Evidence at transcript level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT COILED 27..79
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 187 AA; 21692 MW; 7A8363CC7559B962 CRC64;
MPEVERKPKI TASRKLLLKS LMLAKAKECW EQEHEEREAE KVRYLAERIP TLQTRGLSLS
ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK VMDLRGKFKR PPLRRVRVSA
DAMLRALLGS KHKVSMDLRA NLKSVKKEDT EKERPVEVGD WRKNVEAMSG MEGRKKMFDA
AKSPTSQ
//
