ID H2Q105_PANTR Unreviewed; 178 AA.
AC H2Q105; A0A2J8QVU1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Interleukin family protein {ECO:0000256|RuleBase:RU368043};
GN Name=IL10 {ECO:0000313|Ensembl:ENSPTRP00000003208.1,
GN ECO:0000313|VGNC:VGNC:52981};
GN Synonyms=IF2A {ECO:0000313|EMBL:CAA9999834.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000003208.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000003208.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:CAA9999834.1}
RP NUCLEOTIDE SEQUENCE.
RA Premzl M.;
RT "Comparative genomic analysis of eutherian interferon genes.";
RL Genomics 112:4749-4759(2020).
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000003208.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Immune regulatory cytokine. {ECO:0000256|RuleBase:RU368043}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU368043}.
CC -!- SIMILARITY: Belongs to the IL-10 family.
CC {ECO:0000256|ARBA:ARBA00008813, ECO:0000256|RuleBase:RU368043}.
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DR EMBL; AACZ04071427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LR760864; CAA9999834.1; -; Genomic_DNA.
DR RefSeq; NP_001129092.2; NM_001135620.2.
DR RefSeq; XP_016783106.1; XM_016927617.1.
DR Ensembl; ENSPTRT00000003488.2; ENSPTRP00000003208.1; ENSPTRG00000001916.2.
DR GeneID; 469657; -.
DR KEGG; ptr:469657; -.
DR CTD; 3586; -.
DR VGNC; VGNC:52981; IL10.
DR GeneTree; ENSGT00950000183124; -.
DR HOGENOM; CLU_127747_0_0_1; -.
DR OMA; VMPKAEN; -.
DR OrthoDB; 4203939at2759; -.
DR TreeFam; TF333253; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000001916; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
DR GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Ensembl.
DR GO; GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0002439; P:chronic inflammatory response to antigenic stimulus; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0042832; P:defense response to protozoan; IEA:Ensembl.
DR GO; GO:0010507; P:negative regulation of autophagy; IEA:Ensembl.
DR GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0002875; P:negative regulation of chronic inflammatory response to antigenic stimulus; IEA:Ensembl.
DR GO; GO:0002719; P:negative regulation of cytokine production involved in immune response; IEA:Ensembl.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0032695; P:negative regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR GO; GO:0045347; P:negative regulation of MHC class II biosynthetic process; IEA:Ensembl.
DR GO; GO:0030886; P:negative regulation of myeloid dendritic cell activation; IEA:Ensembl.
DR GO; GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0032689; P:negative regulation of type II interferon production; IEA:Ensembl.
DR GO; GO:1904706; P:negative regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0002904; P:positive regulation of B cell apoptotic process; IEA:Ensembl.
DR GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0001819; P:positive regulation of cytokine production; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; IEA:Ensembl.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:1900100; P:positive regulation of plasma cell differentiation; IEA:Ensembl.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR GO; GO:1903672; P:positive regulation of sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1903034; P:regulation of response to wounding; IEA:Ensembl.
DR GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000098; IL-10.
DR InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR InterPro; IPR020423; IL-10_CS.
DR PANTHER; PTHR48394:SF1; INTERLEUKIN-10; 1.
DR PANTHER; PTHR48394; INTERLEUKIN-19-RELATED; 1.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01294; INTRLEUKIN10.
DR SMART; SM00188; IL10; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU368043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR620443-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU368043};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU368043}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU368043"
FT CHAIN 19..178
FT /note="Interleukin family protein"
FT /evidence="ECO:0000256|RuleBase:RU368043"
FT /id="PRO_5015092350"
FT DISULFID 30..126
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-50"
FT DISULFID 80..132
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-50"
SQ SEQUENCE 178 AA; 20545 MW; 61AEFB63C837CDFB CRC64;
MHSSALLCCL VLLTGVRASP GQGTQSENSC THFPGNLPNM LRDLRDAFSR VKTFFQMKDQ
LDNLLLKESL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN QDPDIKVHVN SLGENLKTLR
LRLRRCHRFL PCENKSKAVE QVKNAFNKLQ EKGIYKAMSE FDIFINYIEA YMTMKIRN
//
