ID H2Q1T7_PANTR Unreviewed; 809 AA.
AC H2Q1T7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Zinc finger protein 33B {ECO:0000313|Ensembl:ENSPTRP00000004176.7};
GN Name=ZNF33B {ECO:0000313|Ensembl:ENSPTRP00000004176.7,
GN ECO:0000313|VGNC:VGNC:7876};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000004176.7, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000004176.7, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000004176.7}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AACZ04049701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2Q1T7; -.
DR PaxDb; 9598-ENSPTRP00000032246; -.
DR Ensembl; ENSPTRT00000004524.7; ENSPTRP00000004176.7; ENSPTRG00000002430.6.
DR VGNC; VGNC:7876; ZNF33B.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162173; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; H2Q1T7; -.
DR TreeFam; TF337898; -.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000002430; Expressed in pituitary gland and 21 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 16.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24384; FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED; 1.
DR PANTHER; PTHR24384:SF218; SI:DKEY-15H8.11 PROTEIN-RELATED; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 15.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 10.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 31..102
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 348..375
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 376..403
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 404..431
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 432..459
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 460..487
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 488..515
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 516..543
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 544..571
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 572..599
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 600..627
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 628..655
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 656..683
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 684..711
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 712..739
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 740..767
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 768..802
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 809 AA; 93940 MW; 3A3C9EEED35E9E94 CRC64;
FSNSAVSSEL SPSFQEQNKM NKVDQKFQGS VSFKDVTVGF TQEEWQHLDP SQRALYRDVM
LENYSNLVSV GYCAHKPEVI FRLEQGEEPW RLEEEFPSQS FPEVWTADHL KERSQENQSK
HLWEVVFINN EMLTKEQGNV IGIPFNMDIS SFPSRKMFCQ YDSCGMSFNT VSELVISKIN
YLGKKSDEFN ACGKLLLNIK HDETHTREKN EVLKNRNTLS HRENTLQHEK IQTLEHNFEY
SICQETLLEK AVFNTRKREN AEENNCDYNE FGRTFCDSSS LLFHQIPPSK DSHYEFSDCE
KFLCVKSTLS KHDGVPVKHY DCGESGNNFR RKLCLSQLQR DDKGEKHFEC NECGKAFWEK
SHLTRHQRVH TGEKRFQCNQ CGKTFWEKSN LTKHQRSHTG EKPFECNECG KAFSHKSALT
LHQRTHTGEK PYQCNACGKT FYQKSDLTKH QRTHTGQKPY ECYECGKSFC MNSHLTVHQR
THTGEKPFEC LECGKSFCQK SHLTQHQRTH IGDKPYECNA CGKTFYHKSV LTRHQIIHTG
LKPYECYECG KTFCLKSDLT VHQRTHTGEK PFACPECGKF FSHKSTLSQH YRTHTGEKPY
ECHECGKIFY NKSYLTKHNR THTGEKPYEC NECGKTFCQK SQLTQHQRIH IGEKPYECNE
CGKAFCHKSA LIVHQRTHTQ EKPYKCNECG KSFCVKSGLI LHERKHTGEK PYECNECGKS
FSHKSSLTVH HRAHTGEKSC QCNECGKIFY RKSDLAKHQR SHTGEKPYEC NTCRKTFSQK
SNLIPQVSLH NASESSHCGE RPVDILNVQ
//
