ID H2Q278_PANTR Unreviewed; 242 AA.
AC H2Q278;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Outer mitochondrial transmembrane helix translocase {ECO:0000256|ARBA:ARBA00040718};
GN Name=ATAD1 {ECO:0000313|Ensembl:ENSPTRP00000004742.2,
GN ECO:0000313|VGNC:VGNC:7840};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000004742.2, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000004742.2, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000004742.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-with a C-terminal TM segment(out) + ATP + H2O =
CC [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:66168, Rhea:RHEA-COMP:16963, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:90782, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00036758};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004572}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00037805}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00037805}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family. MSP1 subfamily.
CC {ECO:0000256|ARBA:ARBA00038383}.
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DR EMBL; AACZ04051030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016774307.1; XM_016918818.1.
DR AlphaFoldDB; H2Q278; -.
DR Ensembl; ENSPTRT00000005131.2; ENSPTRP00000004742.2; ENSPTRG00000002717.3.
DR VGNC; VGNC:7840; ATAD1.
DR eggNOG; KOG0737; Eukaryota.
DR GeneTree; ENSGT00550000074823; -.
DR HOGENOM; CLU_000688_21_14_1; -.
DR OrthoDB; 102713at2759; -.
DR TreeFam; TF105016; -.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000002717; Expressed in testis and 21 other cell types or tissues.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45644; AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED; 1.
DR PANTHER; PTHR45644:SF2; OUTER MITOCHONDRIAL TRANSMEMBRANE HELIX TRANSLOCASE; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU003651};
KW Membrane {ECO:0000256|ARBA:ARBA00022787};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00022787};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003651};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 6..142
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 242 AA; 27231 MW; F7D75CBA92CDFE7D CRC64;
MNYIIFVSGV LLYGPPGCGK TLIAKATAKE AGCRFINLQP STLTDKWYGE SQKLAAAVFS
LAIKLQPSII FIDEIDSFLR NRSSSDHEAT AMMKAQFMSL WDGLDTDHSC QVIVMGATNR
PQDLDSAIMR RMPTRFHINQ PALKQREAIL KLILKNENVD RHVDLLEVAQ ETDGFSGSDL
KEMCRDAALL CVREYVNSTS EESHDEDEIR PVQQQDLHRA IEKMKKSKDA AFQNVLTHVC
LD
//
