ID H2Q2B2_PANTR Unreviewed; 490 AA.
AC H2Q2B2; A0A2J8PE05;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Cytochrome P450 family 2 subfamily C member 8 {ECO:0000313|Ensembl:ENSPTRP00000004854.3};
GN Name=CYP2C8 {ECO:0000313|Ensembl:ENSPTRP00000004854.3,
GN ECO:0000313|VGNC:VGNC:6150};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000004854.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000004854.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000004854.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; AACZ04051073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001153207.1; XM_001153207.4.
DR AlphaFoldDB; H2Q2B2; -.
DR STRING; 9598.ENSPTRP00000004854; -.
DR PaxDb; 9598-ENSPTRP00000004854; -.
DR Ensembl; ENSPTRT00000005250.4; ENSPTRP00000004854.3; ENSPTRG00000002781.6.
DR GeneID; 450909; -.
DR KEGG; ptr:450909; -.
DR CTD; 1558; -.
DR VGNC; VGNC:6150; CYP2C8.
DR eggNOG; KOG0156; Eukaryota.
DR GeneTree; ENSGT00940000163696; -.
DR HOGENOM; CLU_001570_22_3_1; -.
DR InParanoid; H2Q2B2; -.
DR OMA; SFTTTEW; -.
DR OrthoDB; 2900138at2759; -.
DR TreeFam; TF352043; -.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000002781; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0008392; F:arachidonic acid epoxygenase activity; IBA:GO_Central.
DR GO; GO:0034875; F:caffeine oxidase activity; IEA:Ensembl.
DR GO; GO:0101020; F:estrogen 16-alpha-hydroxylase activity; IEA:Ensembl.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IBA:GO_Central.
DR GO; GO:0008401; F:retinoic acid 4-hydroxylase activity; IEA:Ensembl.
DR GO; GO:0019373; P:epoxygenase P450 pathway; IBA:GO_Central.
DR GO; GO:0008210; P:estrogen metabolic process; IEA:Ensembl.
DR GO; GO:0046456; P:icosanoid biosynthetic process; IEA:Ensembl.
DR GO; GO:0002933; P:lipid hydroxylation; IEA:Ensembl.
DR GO; GO:0070989; P:oxidative demethylation; IEA:Ensembl.
DR GO; GO:0042573; P:retinoic acid metabolic process; IEA:Ensembl.
DR GO; GO:0042178; P:xenobiotic catabolic process; IEA:Ensembl.
DR GO; GO:0006805; P:xenobiotic metabolic process; IBA:GO_Central.
DR CDD; cd20665; CYP2C-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24300:SF317; CYTOCHROME P450 2C8; 1.
DR PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..490
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015092387"
SQ SEQUENCE 490 AA; 55626 MW; 1E6306F1FC57D7A3 CRC64;
MEPFVVLVLC LSFMLLFSLW RQSSGRRKLP PGPTPLPIIG NMLQIDVKDI CKSFSNFSKV
YGPVFTVYFG MNPIVVLHGY EAVKEALIDN GEEFSGRGSS PISQRITKGL GIISSNGKRW
KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS
VVFQKRFDYK DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLTNVALT
QSYIREKVKE HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE
TTSTTLRYGL LLLLMHPEVT AKVQEEIDHV IGRHRTPCMQ DRSHMPYTDA VVHEIQRYSD
LVPTGVPHAV TTDTKFRNYL IPKGTTIMTL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK
KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP
PSYQICFIPV
//
