ID H2Q2R3_PANTR Unreviewed; 265 AA.
AC H2Q2R3; A0A2J8JPG6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109};
DE EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109};
DE AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing] {ECO:0000256|ARBA:ARBA00032649};
DE AltName: Full=Uroporphyrinogen-III cosynthase {ECO:0000256|ARBA:ARBA00031702};
GN Name=UROS {ECO:0000313|EMBL:JAA12526.1,
GN ECO:0000313|Ensembl:ENSPTRP00000005362.4, ECO:0000313|VGNC:VGNC:9782};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000005362.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000005362.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA12526.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA36569.1}, Skin
RC {ECO:0000313|EMBL:JAA26726.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA12526.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000005362.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004772}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000256|ARBA:ARBA00008133}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04039300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABF01009619; JAA12526.1; -; mRNA.
DR EMBL; GABD01006374; JAA26726.1; -; mRNA.
DR EMBL; GABE01008170; JAA36569.1; -; mRNA.
DR RefSeq; XP_016775101.1; XM_016919612.1.
DR STRING; 9598.ENSPTRP00000005362; -.
DR PaxDb; 9598-ENSPTRP00000005362; -.
DR Ensembl; ENSPTRT00000005791.5; ENSPTRP00000005362.4; ENSPTRG00000003042.7.
DR VGNC; VGNC:9782; UROS.
DR eggNOG; KOG4132; Eukaryota.
DR GeneTree; ENSGT00390000009853; -.
DR HOGENOM; CLU_051874_1_1_1; -.
DR OMA; CDSMLRG; -.
DR OrthoDB; 1472480at2759; -.
DR TreeFam; TF324092; -.
DR UniPathway; UPA00251; UER00320.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000003042; Expressed in bone marrow and 21 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IBA:GO_Central.
DR GO; GO:0006784; P:heme A biosynthetic process; IEA:Ensembl.
DR GO; GO:0006785; P:heme B biosynthetic process; IEA:Ensembl.
DR GO; GO:0048034; P:heme O biosynthetic process; IEA:Ensembl.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IBA:GO_Central.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR12390; UROPORPHYRINOGEN III SYNTHASE; 1.
DR PANTHER; PTHR12390:SF0; UROPORPHYRINOGEN-III SYNTHASE; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 19..252
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 265 AA; 28660 MW; DD4D0EC7F8B5ECB5 CRC64;
MKVLLLKDAK EDDCGQDPYI RELGLYGLEA TLIPVLSFEF LSLPSFSEKL SHPEDYGGLI
FTSPRAVEAA ELCLEQNNKT EVWERSLKEK WNAKSVYVVG NATASLVSKI GLDTEGETCG
NAEKLAEYIC SRESSALPLL FPCGNLKREI LPKALKDKGI AMESITVYQT IAHPGMQGNL
NSYYSQQGVP ASITFFSPSG LTYSLKHIQE LSGDNIDQIK FAAIGPTTAR ALAAQGLPVS
CTAESPTPQA LATGIRKALQ PHGCC
//
