ID H2Q4H2_PANTR Unreviewed; 260 AA.
AC H2Q4H2; A0A2J8MBQ4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Potassium channel tetramerisation domain containing 21 {ECO:0000313|EMBL:JAA01110.1};
DE SubName: Full=Potassium channel tetramerization domain containing 21 {ECO:0000313|Ensembl:ENSPTRP00000089935.1};
GN Name=KCTD21 {ECO:0000313|EMBL:JAA01110.1,
GN ECO:0000313|Ensembl:ENSPTRP00000089935.1, ECO:0000313|VGNC:VGNC:1082};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000089935.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000089935.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA01110.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA01110.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA34056.1}, Skin {ECO:0000313|EMBL:JAA29850.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA13608.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000089935.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; AACZ04016310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01010228; JAA01110.1; -; mRNA.
DR EMBL; GABF01008537; JAA13608.1; -; mRNA.
DR EMBL; GABF01008536; JAA13609.1; -; mRNA.
DR EMBL; GABD01003250; JAA29850.1; -; mRNA.
DR EMBL; GABE01010683; JAA34056.1; -; mRNA.
DR EMBL; GABE01010682; JAA34057.1; -; mRNA.
DR RefSeq; XP_009422088.1; XM_009423813.2.
DR RefSeq; XP_009422089.1; XM_009423814.2.
DR RefSeq; XP_009422090.1; XM_009423815.2.
DR RefSeq; XP_009422091.1; XM_009423816.2.
DR STRING; 9598.ENSPTRP00000089935; -.
DR PaxDb; 9598-ENSPTRP00000007078; -.
DR Ensembl; ENSPTRT00000081359.1; ENSPTRP00000089935.1; ENSPTRG00000044559.1.
DR GeneID; 451447; -.
DR KEGG; ptr:451447; -.
DR CTD; 283219; -.
DR VGNC; VGNC:1082; KCTD21.
DR eggNOG; KOG2723; Eukaryota.
DR GeneTree; ENSGT00940000160906; -.
DR HOGENOM; CLU_088122_0_0_1; -.
DR OMA; ANIFCTS; -.
DR OrthoDB; 2912088at2759; -.
DR TreeFam; TF315332; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000044559; Expressed in thymus and 22 other cell types or tissues.
DR GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd18395; BTB_POZ_KCTD21; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR045763; KCTD11/21_C.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR14499:SF57; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD21; 1.
DR PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF19329; KCTD11_21_C; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Ion channel {ECO:0000313|EMBL:JAA01110.1};
KW Ion transport {ECO:0000313|EMBL:JAA01110.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transport {ECO:0000313|EMBL:JAA01110.1}.
FT DOMAIN 3..72
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 260 AA; 29643 MW; E94BAD422C106070 CRC64;
MSDPITLNVG GKLYTTSLAT LTSFPDSMLG AMFSGKMPTK RDSQGNCFID RDGKVFRYIL
NFLRTSHLDL PEDFQEMGLL RREADFYQVQ PLIEALQEKE VELSKAEKNA MLNITLNQRV
QTVHFTVREA PQIYSLSSSS MEVFNANIFS TSCLFLKLLG SKLFYCSNGN LSSITSHLQD
PNHLTLDWVA NVEGLPEEEY TKQNLKRLWV VPANKQINSF QVFVEEVLKI ALSDGFCIDS
SHPHALDFMN NKIIRLIRYR
//
