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Database: UniProt
Entry: H2Q4H4_PANTR
LinkDB: H2Q4H4_PANTR
Original site: H2Q4H4_PANTR 
ID   H2Q4H4_PANTR            Unreviewed;      2769 AA.
AC   H2Q4H4; A0A2J8MBS0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 73.
DE   SubName: Full=Teneurin transmembrane protein 4 {ECO:0000313|Ensembl:ENSPTRP00000007086.5};
GN   Name=TENM4 {ECO:0000313|Ensembl:ENSPTRP00000007086.5,
GN   ECO:0000313|VGNC:VGNC:990};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000007086.5, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000007086.5, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000007086.5}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC       Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC       {ECO:0000256|ARBA:ARBA00009385}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AACZ04016314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016777207.1; XM_016921718.1.
DR   STRING; 9598.ENSPTRP00000007086; -.
DR   PaxDb; 9598-ENSPTRP00000007086; -.
DR   Ensembl; ENSPTRT00000007680.5; ENSPTRP00000007086.5; ENSPTRG00000004118.5.
DR   VGNC; VGNC:990; TENM4.
DR   eggNOG; KOG4659; Eukaryota.
DR   GeneTree; ENSGT01030000234566; -.
DR   HOGENOM; CLU_000229_0_0_1; -.
DR   InParanoid; H2Q4H4; -.
DR   OrthoDB; 5491728at2759; -.
DR   TreeFam; TF316833; -.
DR   Proteomes; UP000002277; Chromosome 11.
DR   Bgee; ENSPTRG00000004118; Expressed in pituitary gland and 14 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050839; F:cell adhesion molecule binding; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR   GO; GO:0060912; P:cardiac cell fate specification; IEA:Ensembl.
DR   GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0032289; P:central nervous system myelin formation; IEA:Ensembl.
DR   GO; GO:0001702; P:gastrulation with mouth forming second; IEA:Ensembl.
DR   GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR   GO; GO:0048666; P:neuron development; IBA:GO_Central.
DR   GO; GO:2000543; P:positive regulation of gastrulation; IEA:Ensembl.
DR   GO; GO:0031643; P:positive regulation of myelination; IEA:Ensembl.
DR   GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00054; EGF_CA; 1.
DR   Gene3D; 2.10.25.10; Laminin; 7.
DR   Gene3D; 2.180.10.10; RHS repeat-associated core; 2.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR022385; Rhs_assc_core.
DR   InterPro; IPR031325; RHS_repeat.
DR   InterPro; IPR009471; Ten_N.
DR   InterPro; IPR028916; Tox-GHH_dom.
DR   InterPro; IPR006530; YD.
DR   NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR   NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR   PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   PANTHER; PTHR11219:SF9; TENEURIN-4; 1.
DR   Pfam; PF07974; EGF_2; 2.
DR   Pfam; PF05593; RHS_repeat; 1.
DR   Pfam; PF06484; Ten_N; 2.
DR   Pfam; PF15636; Tox-GHH; 1.
DR   SMART; SM00181; EGF; 8.
DR   SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR   SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   SUPFAM; SSF101898; NHL repeat; 1.
DR   PROSITE; PS00022; EGF_1; 5.
DR   PROSITE; PS01186; EGF_2; 4.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS51361; TENEURIN_N; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        341..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..341
FT                   /note="Teneurin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51361"
FT   DOMAIN          626..658
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          756..787
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          796..831
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          130..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..157
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        648..657
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        760..770
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        777..786
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        800..810
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        821..830
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   2769 AA;  308021 MW;  A2F7159C0A64A8A0 CRC64;
     MDVKERKPYR SLTRRRDAER RYTSSSADSE EGKAPQKSYS SSETLKAYDQ DARLAYGSRV
     KDIVPQEAEE FCRTGANFTL RELGLEEVTP PHGTLYRTDI GLPHCGYSMG AGSDADMEAD
     TVLSPEHPVR LWGRSTRSGR SSCLSSRANS NLTLTDTEHE NTETDHPGGL QNHARLRTPP
     PPLSHAHTPN QHHAASINSL NRGNFTPRSN PSPAPTDHSL SGEPPAGGAQ EPAHAQDNWL
     LNSNIPLETR NLGKQPFLGT LQDNLIEMDI LGTSRHDGAY SDGHFLFKPG GTSPLFCTTS
     PGYPLTSSTV YSPPPRPLPR STFARPAFNL KKPSKYCNWK CAALSAIVIS ATLVILLAYF
     VAMHLFGLNW HLQPMEGQMY EITEDTASSW PVPTDVSLYP SGGTGLETPD RKGKGTTEGK
     PSSFFPEDSF IDSGEIDVGR RASQKIPPGT FWRSQVFIDH PVHLKFNVSL GKAALVGIYG
     RKGLPPSHTQ FDFVELLDGR RLLIQEARSL EGTPRQSRGT VPPSSHETGF IQYLDSGIWH
     LAFYNDGKES EVVSFLTTAI ESVDNCPSNC YGNGDCISGT CHCFLGFLGP DCGRASCPVL
     CSGNGQYMKG RCLCHSGWKG AECDVPTNQC IDVACSNHGT CITGTCICNP GYKGESCEEV
     DCMDPTCSGR GVCVRGECHC SVGWGGTNCE TPRATCLDQC SGHGTFLQDT GLCSCDPSWT
     GHDCSIEICA ADCGGHGVCV GGTCRCEDGW MGAACDQRAC HPRCAEHGTC RDGKCECSPG
     WNGEHCTIAH YLDRVVKEGC PGLCNGNGRC TLDLNGWHCV CQLGWRGAGC DTSMETACGD
     SKDNDGDGLL DCMDPDCCLQ PMCHINPLCL GSPNPLDIIQ ETQVPVSQQN LHSFYDRIKF
     LVGRDSTHII PGENPFDGGH ACVIRGQVMT SDGTPLVGVN ISFVNNPLFG YTISRQDGSF
     DLVTNGGISI ILRFERAPFI TQEHTLWLPW DRFFVMETII MRHEENEIPS CDLSNFARPN
     PVVSPSPLTS FASSCAEKGP IVPEIQALQE EISISGCKMR LSYLSSRTPG YKSVLRISLT
     HPTIPFNLMK VHLMVAVEGR LFRKWFAAAP DLSYYFIWDK TDVYNQKVFG LSEAFVSVGY
     EYESCPDLIL WEKRTAVLQG YEIDASKLGG WSLDKHHALN IQSGILHKGN GENQFVSQQP
     PVIGSIMGNG RRRSISCPSC NGLADGNKLL APVALTCGSD GSLYVGDFNY IRRIFPSGNV
     TNILELRNKD FRHSHSPAHK YYLTTDPMSG AVFLSDSNSR RVFKIKSTVV VKDLVKNSEV
     VAGTGDQCLP FDDTRCGDGG KATEATLTNP RGITVDKFGL IYFVDGTMIR RIDQNGIIST
     LLGSNDLTSA RPLSCDSVMD ISQVHLEWPT DLAINPMDNS LYVLDNNVVL QISENHQVRI
     VAGRPMHCQV PGIDHFLLSK VAIHATLESA TALAVSHNGV LYIAETDEKK INRIRQVTTS
     GEISLVAGAP SGCDCKNDAN CDCFSGDDGY AKDAKLNTPS SLAVCADGEL YVADLGNIRI
     RFIRKNKPFL NTQNMYELSS PIDQELYLFD TTGKHLYTQS LPTGDYLYNF TYTGDGDITL
     ITDNNGNMVN VRRDSTGMPL WLVVPDGQVY WVTMGTNSAL KSVTTQGHEL AMMTYHGNSG
     LLATKSSENG WTTFYEYDSF GRLTNVTFPT GQVSSFRSDT DSSVHVQVET SSKDDVTITT
     NLSASGAFYT LLQDQVRNSY YIGADGSLRL LLANGMEVAL QTEPHLLAGT VNPTVGKRNV
     TLPIDNGLNL VEWRQRKEQA RGQVTVFGRR LRVHNRNLLS LDFDRVTRTE KIYDDHRKFT
     LRILYDQAGR PSLWSPSSRL NGVNVTYSPG GYIAGIQRGI MSERMEYDQA GRITSRIFAD
     GKTWSYTYLE KSMVLLLHSQ RQYIFEFDKN DRLSSVTMPN VARQTLETIR SVGYYRNIYQ
     PPEGNASVIQ DFTEDGHLLH TFYLGTGRRV IYKYGKLSKL AETLYDTTKV GFTYDETAGM
     LKTINLQNEG FTCTIRYRQI GPLIDRQIFR FTEEGMVNAR FDYNYDNSFR VTSMQAVINE
     TPLPIDLYRY DDVSGKTEQF GKFGVIYYDI NQIITTAVMT HTKHFDAYGR MKEVQYEIFR
     SLMYWMTVQY DNMGRVVKKE LKVGPYANTT RYSYEYDADG QLQTVSINDK PLWRYSYDLN
     GNLHLLSPGN SARLTPLRYD IRDRITRLGD VQYKMDEDGF LRQRGGDIFE YNSAGLLIKA
     YNRAGSWSVR YRYDGLGRRV SSKSSHSHHL QFFYADLTNP TKVTHLYNHS SSEITSLYYD
     LQGHLFAMEL SSGDEFYIAC DNIGTPLAVF SGTGLMIKQI LYTAYGEIYM DTNPNFQIII
     GYHGGLYDPL TKLVHMGRRD YDVLAGRWTS PDHELWKHLS SSNVMPFNLY MFKNNNPISN
     SQDIKCFMTD VNSWLLTFGF QLHNVIPGYP KPDMDAMEPS YELIHTQMKT QEWDNSKSIL
     GVQCEVQKQL KAFVTLERFD QLYGSTITSC QQAPKTKKFA SSSSVFGKGV KFALKDGRVT
     TDIISVANED GRRVAAILNH AHYLENLHFT IDGVDTHYFV KPGPSEGDLA ILGLSGGRRT
     LENGVNVTVS QINTVLNGRT RRYTDIQLQY GALCLNTRYG TTLDEEKARV LELARQRAVR
     QAWAREQQRL REGEEGLRAW TEGEKQQVLS TGRVQGYDGF FVISVEQYPE LSDSANNIHF
     MRQSEMGRR
//
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