ID H2Q4S8_PANTR Unreviewed; 779 AA.
AC H2Q4S8; A0A2J8L011;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=ZW10, kinetochore associated, homolog {ECO:0000313|EMBL:JAA07755.1};
DE SubName: Full=Zw10 kinetochore protein {ECO:0000313|Ensembl:ENSPTRP00000007380.3};
GN Name=ZW10 {ECO:0000313|EMBL:JAA07755.1,
GN ECO:0000313|Ensembl:ENSPTRP00000007380.3, ECO:0000313|VGNC:VGNC:930};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000007380.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000007380.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA07755.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA07755.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA41258.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA19680.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000007380.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}.
CC -!- SIMILARITY: Belongs to the ZW10 family.
CC {ECO:0000256|ARBA:ARBA00006245}.
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DR EMBL; AACZ04006772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01003583; JAA07755.1; -; mRNA.
DR EMBL; GABF01002465; JAA19680.1; -; mRNA.
DR EMBL; GABE01003481; JAA41258.1; -; mRNA.
DR RefSeq; XP_508761.2; XM_508761.5.
DR STRING; 9598.ENSPTRP00000007380; -.
DR PaxDb; 9598-ENSPTRP00000007380; -.
DR Ensembl; ENSPTRT00000007998.4; ENSPTRP00000007380.3; ENSPTRG00000004297.4.
DR GeneID; 451554; -.
DR CTD; 9183; -.
DR VGNC; VGNC:930; ZW10.
DR eggNOG; KOG2163; Eukaryota.
DR GeneTree; ENSGT00390000016427; -.
DR HOGENOM; CLU_012948_0_0_1; -.
DR OMA; TWPRMSE; -.
DR OrthoDB; 2786073at2759; -.
DR TreeFam; TF105966; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000004297; Expressed in fibroblast and 21 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0070939; C:Dsl1/NZR complex; IEA:Ensembl.
DR GO; GO:0005828; C:kinetochore microtubule; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:1990423; C:RZZ complex; IBA:GO_Central.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0007080; P:mitotic metaphase chromosome alignment; IEA:Ensembl.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IBA:GO_Central.
DR GO; GO:0034501; P:protein localization to kinetochore; IEA:Ensembl.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0007096; P:regulation of exit from mitosis; IEA:Ensembl.
DR Gene3D; 1.10.357.150; -; 1.
DR InterPro; IPR046362; Zw10/DSL1_C_sf.
DR InterPro; IPR048343; ZW10_C.
DR InterPro; IPR048344; Zw10_middle.
DR InterPro; IPR009361; Zw10_N.
DR PANTHER; PTHR12205; CENTROMERE/KINETOCHORE PROTEIN ZW10; 1.
DR PANTHER; PTHR12205:SF0; CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG; 1.
DR Pfam; PF20666; ZW10_C; 1.
DR Pfam; PF20665; Zw10_middle; 1.
DR Pfam; PF06248; Zw10_N; 1.
PE 2: Evidence at transcript level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 27..119
FT /note="Centromere/kinetochore protein zw10 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06248"
FT DOMAIN 177..415
FT /note="Centromere/kinetochore protein zw10 middle"
FT /evidence="ECO:0000259|Pfam:PF20665"
FT DOMAIN 472..602
FT /note="Centromere/kinetochore protein zw10 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20666"
FT COILED 17..83
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 779 AA; 88829 MW; 9C38186153886481 CRC64;
MASFVTEVLA HSGRLEKEDL GTRISRLTRR VEEIKGEVCN MISKKYSEFL PSMQSAQGLI
TQVDKLSEDI DLLKSRIESE VRRDLHVSTG EFTDLKQQLE RDSVVLSLLK QLQEFSTAIE
EYNCALTEKK YVTGAQRLEE AQKCLKLLKS RKCFDLKILK SLSMELTIQK QNILYHLGEE
WQKLIVWKFP PSKDTSSLES YLQTELHLYT EQSHKEEKTP MPPISSVLLA FSVLGELHSK
LKSFGQMLLK YILRPLASCP SLHAVIESQP NIVIIRFESI MTNLEYPSPS EVFTKIRLVL
EVLQKQLLDL PLDTDLENEK TSTVPLAEML GDMIWEDLSE CLIKNCLVYS IPTNSSKLQQ
YEEIIQSTEE FENALKEMRF LKGDTTDLLK YARNINSHFA NKKCQDVIVA ARNLMTSEIH
NTVKIIPDSK INVPELPTPD EDNKLEVQKV SNTQYHEVMN LEPENTLDQH SFSLPTCRIS
ESVKKLMELA YQTLLEATTS SDQCAVQLFY SVRNIFHLFH DVVPTYHKEN LQKLPQLAAI
HHNNCMYIAH HLLTLGHQFR LRLAPILCDG TATFVDLVPG FRRLGTECFL AQMRAQKGEL
LERLSSARNF SNMDDEENYS AASKAVRQVL HQLKRLGIVW QDVLPVNIYC KAMGTLLNTA
ISEVIGKITA LEDISTEDGD RLYSLCKTVM DEGPQVFAPL SEESKNKKYQ EEVPVYVPKW
MPFKELMMML QASLQEIGDR WADGKGPLAA AFSSSEVKAL IRALFQNTER RAAALAKIK
//
