ID H2Q528_PANTR Unreviewed; 481 AA.
AC H2Q528; A0A2J8N1E1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Pseudouridine synthase 3 {ECO:0000313|Ensembl:ENSPTRP00000007600.3};
DE SubName: Full=Pseudouridylate synthase 3 {ECO:0000313|EMBL:JAA03129.1};
GN Name=PUS3 {ECO:0000313|EMBL:JAA03129.1,
GN ECO:0000313|Ensembl:ENSPTRP00000007600.3, ECO:0000313|VGNC:VGNC:1034};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000007600.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000007600.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA03129.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03129.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA33197.1}, Skin {ECO:0000313|EMBL:JAA28489.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA16910.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000007600.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
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DR EMBL; AACZ04006708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01008209; JAA03129.1; -; mRNA.
DR EMBL; GABF01005235; JAA16910.1; -; mRNA.
DR EMBL; GABD01004611; JAA28489.1; -; mRNA.
DR EMBL; GABE01011542; JAA33197.1; -; mRNA.
DR RefSeq; XP_001148378.1; XM_001148378.2.
DR RefSeq; XP_009422719.1; XM_009424444.2.
DR STRING; 9598.ENSPTRP00000007600; -.
DR PaxDb; 9598-ENSPTRP00000007600; -.
DR Ensembl; ENSPTRT00000008236.4; ENSPTRP00000007600.3; ENSPTRG00000004449.4.
DR GeneID; 740256; -.
DR KEGG; ptr:740256; -.
DR CTD; 83480; -.
DR VGNC; VGNC:1034; PUS3.
DR eggNOG; KOG2554; Eukaryota.
DR GeneTree; ENSGT00950000183160; -.
DR HOGENOM; CLU_014673_2_0_1; -.
DR OMA; DCKFPEM; -.
DR OrthoDB; 167554at2759; -.
DR TreeFam; TF314428; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000004449; Expressed in hindlimb stylopod muscle and 21 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:1990481; P:mRNA pseudouridine synthesis; IBA:GO_Central.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IBA:GO_Central.
DR CDD; cd02569; PseudoU_synth_ScPus3; 1.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR HAMAP; MF_00171; TruA; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR041707; Pus3-like.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR NCBIfam; TIGR00071; hisT_truA; 1.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF5; TRNA PSEUDOURIDINE(38_39) SYNTHASE; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 2: Evidence at transcript level;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 212..330
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT REGION 29..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 55623 MW; DA05BF3740444E8A CRC64;
MADNDTDRNQ TEKLLKRVRE LEQEVQRLKK EQAKNKEDSN IRENSSGAGK TKRAFDFSAH
GRRHVALRIA YMGWGYQGFA SQENTNNTIE EKLFEALTKT RLVESRQTSN YHRCGRTDKG
VSAFGQVISL DLRSHFPRGR DSEDFNVKEE ANAAAEEIRY THILNRVLPP DIRILAWAPV
EPSFSARFSC LERTYRYFFP RADLDIVTMD YAAQKYVGTH DFRNLCKMDV ANGVINFQRT
ILSAQVQLVG QSPGEGRWQE PFQLCQFEVT GQAFLYHQVR CMMAILFLIG QGMEKPEIID
ELLNIEKNPQ KPQYSMAVEF PLVLYDCKFE NVKWIYDQEA QEFNITHLQQ LWANHAVKTH
MLYSMLQGLD TVPVPCGIGP KMDGMTEWGN VKPSVIKQTS AFVEGVKMRT YKPLMNRPKC
QGLESRIQHF VRRGRIEHPH LFHEEETKAK RDCNDTLEEE NTNLETPTKR VCVDTEIKSI
I
//
