ID H2Q5D1_PANTR Unreviewed; 573 AA.
AC H2Q5D1; A0A2J8JE32;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Forkhead box J2 {ECO:0000313|EMBL:JAA16939.1, ECO:0000313|Ensembl:ENSPTRP00000007900.3};
GN Name=FOXJ2 {ECO:0000313|EMBL:JAA16939.1,
GN ECO:0000313|Ensembl:ENSPTRP00000007900.3, ECO:0000313|VGNC:VGNC:5392};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000007900.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000007900.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA16939.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA39857.1}, and Smooth
RC vascular {ECO:0000313|EMBL:JAA16939.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000007900.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; AACZ04028186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABF01005206; JAA16939.1; -; mRNA.
DR EMBL; GABE01004882; JAA39857.1; -; mRNA.
DR EMBL; GABE01004881; JAA39858.1; -; mRNA.
DR RefSeq; XP_001166729.1; XM_001166729.4.
DR STRING; 9598.ENSPTRP00000007900; -.
DR PaxDb; 9598-ENSPTRP00000007900; -.
DR Ensembl; ENSPTRT00000008551.4; ENSPTRP00000007900.3; ENSPTRG00000004629.4.
DR GeneID; 466941; -.
DR KEGG; ptr:466941; -.
DR CTD; 55810; -.
DR VGNC; VGNC:5392; FOXJ2.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000161053; -.
DR HOGENOM; CLU_034661_0_0_1; -.
DR OMA; SHFSELM; -.
DR OrthoDB; 5385885at2759; -.
DR TreeFam; TF333250; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000004629; Expressed in hindlimb stylopod muscle and 21 other cell types or tissues.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007141; P:male meiosis I; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0110059; P:negative regulation of blood vessel endothelial cell differentiation; IEA:Ensembl.
DR GO; GO:1904707; P:positive regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd20051; FH_FOXJ2; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047393; FH_FOXJ2.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR045912; FOXJ2/3-like.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46078:SF1; FORKHEAD BOX PROTEIN J2; 1.
DR PANTHER; PTHR46078; FORKHEAD BOX PROTEIN J2 FAMILY MEMBER; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 66..143
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 66..143
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 26..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..316
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..397
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 62283 MW; 5F359040BD37CDC9 CRC64;
MASDLESSLT SIDWLPQLTL RATIEKLGSA SQAGPPGSSR KCSPGSPTDP NATLSKDEAA
VHQDGKPRYS YATLITYAIN SSPAKKMTLS EIYRWICDNF PYYKNAGIGW KNSIRHNLSL
NKCFRKVPRP RDDPGKGSYW TIDTCPDISR KRRHPPDDDL SQDSPEQEAS KSPRGGVAGS
GEASLPPEGN PQMSLQSPTS IASYSQGTGS VDGGAVAAGA SGRESAEGPP PLYNTNHDFK
FSYSEINFQD LSWSFRNLYK SMLEKSSPSS QHGFSSLLGD IPPSNNYYMY QQQQPPPPQQ
QQQQQPPQPP PQQSQPQQQQ APAQGPSAVG GAPPLHTPSP DGCTPPGGKQ AGAEGYGPPP
VMAMHPPPLQ HGGYHPHQHH PHSHPAQQPP PPQPQAQGQA PINNTGFAFP SDWCSNIDSL
KESFKMVNRL NWSSIEQSQF SELMESLRQA EQKNWTLDQH HIANLCDSLN HFLTQTGHVP
PQGGTHRPPA PARIADSCAL TSGKQESAMS QVNSYGHPQA PHLYPGPSPM YPIPTQDSAG
YNRPAHHMVP RPPVPPPGAN EEIPDDFDWD LIT
//
