ID   H2Q5I8_PANTR            Unreviewed;       273 AA.
AC   H2Q5I8; A0A2J8QQ41;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Endoplasmic reticulum protein 27 {ECO:0000313|Ensembl:ENSPTRP00000008070.2};
GN   Name=ERP27 {ECO:0000313|Ensembl:ENSPTRP00000008070.2,
GN   ECO:0000313|VGNC:VGNC:8406};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000008070.2, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000008070.2, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000008070.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC       {ECO:0000256|ARBA:ARBA00006347}.
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DR   EMBL; AACZ04031285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_001158430.1; XM_001158430.3.
DR   AlphaFoldDB; H2Q5I8; -.
DR   STRING; 9598.ENSPTRP00000008070; -.
DR   PaxDb; 9598-ENSPTRP00000008070; -.
DR   Ensembl; ENSPTRT00000008733.3; ENSPTRP00000008070.2; ENSPTRG00000004728.3.
DR   KEGG; ptr:741952; -.
DR   VGNC; VGNC:8406; ERP27.
DR   eggNOG; KOG0191; Eukaryota.
DR   GeneTree; ENSGT00930000151058; -.
DR   HOGENOM; CLU_088451_0_0_1; -.
DR   InParanoid; H2Q5I8; -.
DR   OMA; EESHGYK; -.
DR   OrthoDB; 4188393at2759; -.
DR   TreeFam; TF106381; -.
DR   Proteomes; UP000002277; Chromosome 12.
DR   Bgee; ENSPTRG00000004728; Expressed in cortex of kidney and 10 other cell types or tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central.
DR   CDD; cd02982; PDI_b'_family; 1.
DR   CDD; cd02981; PDI_b_family; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 2.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR18929:SF193; ENDOPLASMIC RETICULUM RESIDENT PROTEIN 27; 1.
DR   PANTHER; PTHR18929; PROTEIN DISULFIDE ISOMERASE; 1.
DR   Pfam; PF13848; Thioredoxin_6; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 2.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..273
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015092466"
SQ   SEQUENCE   273 AA;  30532 MW;  7FBE207F5EB55301 CRC64;
     MEDAPSRFMF LLFLLTCELA AEVAAEVEKS SDGPGAAQEP TWLADVPAAM EFIAATEVAV
     IGFFQDLEIL AVPILHSMVQ KFPGVSFGIS IDSEVLTHYN ITGNTICLFR LVDNEQLNLE
     DEDIESIDAT KLSRFIEINS LHMVTEYNPV TVIGLFNSII QIHLLLIMNK ASPEYEENMH
     RYQKAAKLFQ GKILFILVDS GVKENGKVIS FFKLKESQLP ALAIYRTLDD EWDTLPTAEV
     SVEHVQNFCD GFLSGKLLKE NRESEGKTPK VEL
//