ID H2Q603_PANTR Unreviewed; 640 AA.
AC H2Q603; A0A2J8KDE2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Keratin 76 {ECO:0000313|Ensembl:ENSPTRP00000008501.2};
GN Name=KRT76 {ECO:0000313|Ensembl:ENSPTRP00000008501.2,
GN ECO:0000313|VGNC:VGNC:8454};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000008501.2, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000008501.2, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000008501.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AACZ04012928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_522397.2; XM_522397.3.
DR AlphaFoldDB; H2Q603; -.
DR STRING; 9598.ENSPTRP00000008501; -.
DR PaxDb; 9598-ENSPTRP00000008501; -.
DR Ensembl; ENSPTRT00000009195.3; ENSPTRP00000008501.2; ENSPTRG00000004990.3.
DR GeneID; 466997; -.
DR KEGG; ptr:466997; -.
DR CTD; 51350; -.
DR VGNC; VGNC:8454; KRT76.
DR eggNOG; ENOG502QSI5; Eukaryota.
DR GeneTree; ENSGT00940000162365; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; H2Q603; -.
DR OMA; MSHSGMG; -.
DR OrthoDB; 4640531at2759; -.
DR TreeFam; TF317854; -.
DR Proteomes; UP000002277; Chromosome 12.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF29; KERATIN, TYPE II CYTOSKELETAL 2 ORAL; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 183..496
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 534..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 187..321
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 394..474
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 535..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 66046 MW; E1974FD236B5027A CRC64;
MNRQVCKKSF SGRSQGFSGR SAVVSGSSRM SCVAHSGGAG GGACGFRSGA GSFGSRSLYN
LGSNKSISIS VAAGGSRAGG FGGGRSSCGF AGGYGGGFGG SYGGGFGGGR GVGSGFGGAG
GFGGAGGFGG PGVFGGPGSF GGPGGFGPGG FPGGIQEVIV NQSLLQPLNV EIDPQIGQVK
AQEREQIKTL NNKFASFIDK VRFLEQQNKV LETKWELLQQ QTTGSGPSSL EPCFESYISF
LRKQLDSLLG ERGNLEGELK SMQDLVEDFK KKYEDEINKR TAAENEFVGL KKDVDAAFMS
KVELQAKVDS LTDEVSFLRT LYEMELSQMQ SHASDTSVVL SMDNNRCLDL DSIIAEVRAQ
YEEIAQRSKA EAEALYQTKL GELQTTAGRH GDDLRNTKSE IMELNRMIQR LRAEIENVKK
QNANLQTAIA EAEQRGEMAL KDANAKLQDL QAALQKAKDD LARLLRDYQE LMNVKLALDV
EIATYRKLLE GEECRMSGEC QSAVCISVVS NVTSTSGSSG SSRAVFGGVS GSGSGGYKGG
SSSSSSSSSG YGVSGGSGSG YGGVSSGSTG GRGSSGSYQS SSSGSRLGGA GGISVSHSGM
DSSSGSIQTS GGSGYKSGGG GSTSIRFSQT TSSSQHSSTK
//
