ID H2Q7P4_PANTR Unreviewed; 958 AA.
AC H2Q7P4; A0A2J8PB88;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=SLIT and NTRK like family member 5 {ECO:0000313|Ensembl:ENSPTRP00000010126.1};
GN Name=SLITRK5 {ECO:0000313|Ensembl:ENSPTRP00000010126.1,
GN ECO:0000313|VGNC:VGNC:5109};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000010126.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000010126.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000010126.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SLITRK family.
CC {ECO:0000256|ARBA:ARBA00010439}.
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DR EMBL; AACZ04072643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003314232.1; XM_003314184.3.
DR RefSeq; XP_009425401.1; XM_009427126.2.
DR RefSeq; XP_522693.3; XM_522693.6.
DR AlphaFoldDB; H2Q7P4; -.
DR STRING; 9598.ENSPTRP00000010126; -.
DR PaxDb; 9598-ENSPTRP00000010126; -.
DR Ensembl; ENSPTRT00000010936.2; ENSPTRP00000010126.1; ENSPTRG00000005957.2.
DR GeneID; 467295; -.
DR KEGG; ptr:467295; -.
DR CTD; 26050; -.
DR VGNC; VGNC:5109; SLITRK5.
DR eggNOG; ENOG502QUVV; Eukaryota.
DR GeneTree; ENSGT00940000158453; -.
DR HOGENOM; CLU_012706_1_0_1; -.
DR InParanoid; H2Q7P4; -.
DR OMA; LTGEMFF; -.
DR OrthoDB; 5309131at2759; -.
DR TreeFam; TF326378; -.
DR Proteomes; UP000002277; Chromosome 13.
DR Bgee; ENSPTRG00000005957; Expressed in dorsolateral prefrontal cortex and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IBA:GO_Central.
DR GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773; SLIT AND NTRK-LIKE PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR45773:SF5; SLIT AND NTRK-LIKE PROTEIN 5; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00082; LRRCT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 665..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 235..285
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 563..613
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 317..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..812
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 107500 MW; CB5266C005E47570 CRC64;
MHTCCPPVTL EQDLHRKMHS WMLQTLAFAV TSLVLSCAET IDYYGEICDN ACPCEEKDGI
LTVSCENRGI ISLSEISPPR FPIYHLLLSG NLLNRLYPNE FVNYTGASIL HLGSNVIQDI
ETGAFHGLRG LRRLHLNNNK LELLRDDTFL GLENLEYLQV DYNYISVIEP NAFGKLHLLQ
VLILNDNLLS SLPNNLFRFV PLTHLDLRGN RLKLLPYVGL LQHMDKVVEL QLEENPWNCS
CELISLKDWL DSISYSALVG DVVCETPFRL HGRDLDEVSK QELCPRRLIS DYEMRPQTPL
STTGYLHTTP ASVNSVATSS SAVYKPPLKP PKGTRQPNKP RVRPTSRQPS KDLGYSNYGP
SIAYQTKSPV PLECPTACTC NLQISDLGLN VNCQERKIES IAELQPKPYN PKKMYLTENY
IAVVRRTDFL EATGLDLLHL GNNRISMIQD RAFGDLTNLR RLYLNGNRIE RLSPELFYGL
QSLQYLFLQY NLIREIQSGT FDPVPNLQLL FLNNNLLQAM PSGVFSGLTL LRLNLRSNHF
TSLPVSGVLD QLKSLIQIDL HDNPWDCTCD IVGMKLWVEQ LKVGVLVDEV ICKAPKKFAE
TDMRSIKSEL LCPDYSDVVV STPTPSSIQV PARTSAVTPA VRLNSTGAPA SLGAGGGASS
VPLSVLILSL LLVFIMSVFV AAGLFVLVMK RRKKNQSDHT STNNSDVSSF NMQYSVYGGG
GGTGGHPHAH VHHRGPALPK VKTPAGHVYE YIPHPLGHMC KNPIYRSREG NSVEDYKDLH
ELKVTYSSNH HLQQQQQPPP PPQQPQQQPP PQLQLQPGEE ERRESHHLRS PAYSVSTIEP
REDLLSPVQD ADRFYRGILE PDKHCSTTPA GNSLPEYPKF PCSPAAYTFS PNYDLRRPHQ
YLHPGAGDSR LREPVLYSPP SAVFVEPNRN EYLELKAKLN VEPDYLEVLE KQTTFSQF
//
