ID H2Q837_PANTR Unreviewed; 678 AA.
AC H2Q837; A0A2J8QKS3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=KH and NYN domain containing {ECO:0000313|EMBL:JAA06262.1, ECO:0000313|Ensembl:ENSPTRP00000010562.4};
GN Name=KHNYN {ECO:0000313|EMBL:JAA06262.1,
GN ECO:0000313|Ensembl:ENSPTRP00000010562.4, ECO:0000313|VGNC:VGNC:3401};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000010562.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000010562.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA06262.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA06262.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA38094.1}, Skin {ECO:0000313|EMBL:JAA25443.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA20304.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000010562.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04059403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01005076; JAA06262.1; -; mRNA.
DR EMBL; GABC01005075; JAA06263.1; -; mRNA.
DR EMBL; GABC01005074; JAA06264.1; -; mRNA.
DR EMBL; GABF01001841; JAA20304.1; -; mRNA.
DR EMBL; GABF01001840; JAA20305.1; -; mRNA.
DR EMBL; GABF01001839; JAA20306.1; -; mRNA.
DR EMBL; GABD01007657; JAA25443.1; -; mRNA.
DR EMBL; GABD01007656; JAA25444.1; -; mRNA.
DR EMBL; GABD01007655; JAA25445.1; -; mRNA.
DR EMBL; GABE01006645; JAA38094.1; -; mRNA.
DR EMBL; GABE01006644; JAA38095.1; -; mRNA.
DR EMBL; GABE01006643; JAA38096.1; -; mRNA.
DR RefSeq; XP_003314329.1; XM_003314281.3.
DR RefSeq; XP_009425879.1; XM_009427604.2.
DR STRING; 9598.ENSPTRP00000010562; -.
DR PaxDb; 9598-ENSPTRP00000010562; -.
DR Ensembl; ENSPTRT00000011415.5; ENSPTRP00000010562.4; ENSPTRG00000006221.5.
DR GeneID; 467412; -.
DR KEGG; ptr:467412; -.
DR CTD; 23351; -.
DR VGNC; VGNC:3401; KHNYN.
DR eggNOG; KOG3777; Eukaryota.
DR GeneTree; ENSGT00940000161993; -.
DR HOGENOM; CLU_014137_0_0_1; -.
DR OMA; NQQQGRE; -.
DR OrthoDB; 180910at2759; -.
DR TreeFam; TF315783; -.
DR Proteomes; UP000002277; Chromosome 14.
DR Bgee; ENSPTRG00000006221; Expressed in hindlimb stylopod muscle and 21 other cell types or tissues.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0004521; F:RNA endonuclease activity; IBA:GO_Central.
DR CDD; cd09032; KH-I_N4BP1_like_rpt1; 1.
DR CDD; cd22477; KH-I_NYNRIN_like; 1.
DR CDD; cd18728; PIN_N4BP1-like; 1.
DR Gene3D; 3.40.50.11980; -; 1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR021869; RNase_Zc3h12_NYN.
DR PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR PANTHER; PTHR12876:SF28; PROTEIN KHNYN; 1.
DR Pfam; PF11977; RNase_Zc3h12a; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 437..589
FT /note="RNase NYN"
FT /evidence="ECO:0000259|Pfam:PF11977"
FT REGION 222..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..368
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..633
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 678 AA; 74517 MW; 0C2A26F400ADB83F CRC64;
MPTWGARPAS PDRFAVTAEA ENKVREQQPH VERIFSVGVS VLPKDCPDNP HIWLQLEGPK
ENASRAKEYL KGLCSPELQD EIHYPPKLHC IFLGAQGFFL DCLAWSTSAH LVPRAPGSLM
ISGLTEAFVM AQSRVEELAE RLSWDFTPGP SSGASQCTGV LRDFSALLRS PGDAHREALL
QLPLAVQEEL LSLVQEASSG QGPGALASWE GRSSALLGAQ CQGVRAPPSD GRESLDTGSM
GPGDSRGARG DTYAVEKEGG KQGGPREMDL GWKELPGEEA WEREVALRPQ SVGGGARESA
PLKGKALGKE EITLGGGGFC VHREPPGAHG SCHRAAQSRG ASLLQRLHNG NASPPRVPSP
PPAPEPPWHC GDRGDCGDRG DVGDRGDKQQ GMARGRGPQW KRGARGGNLV TGTQRFKEAL
QDPFTLCLAN VPGQPDLRHI VIDGSNVAMV HGLQHYFSSR GIAIAVQYFW DRGHRDITVF
VPQWRFSKDA KVRESHFLQK LYSLSLLSLT PSRVMDGKRI SSYDDRFMVK LAEETDGIIV
SNDQFRDLAE ESEKWMAIIR ERLLPFTFVG NLFMVPDDPL GRNGPTLDEF LKKPARTQGS
SKAQHPSRGF AEHGKQQQGR EEEKGSGGIR KTRETERLRR QLLEVFWGQD HKVDFILQRE
PYCRDINQLS EALLSLNF
//
