ID H2Q8A7_PANTR Unreviewed; 614 AA.
AC H2Q8A7; K7B8L1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=FERM domain containing 6 {ECO:0000313|EMBL:JAA10454.1, ECO:0000313|Ensembl:ENSPTRP00000010750.5};
GN Name=FRMD6 {ECO:0000313|EMBL:JAA10454.1,
GN ECO:0000313|Ensembl:ENSPTRP00000010750.5, ECO:0000313|VGNC:VGNC:3421};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000010750.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000010750.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA10454.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA10454.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000010750.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04008565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01000884; JAA10454.1; -; mRNA.
DR RefSeq; XP_001157833.2; XM_001157833.3.
DR Ensembl; ENSPTRT00000011611.5; ENSPTRP00000010750.5; ENSPTRG00000006340.5.
DR GeneID; 467455; -.
DR CTD; 122786; -.
DR VGNC; VGNC:3421; FRMD6.
DR eggNOG; KOG4371; Eukaryota.
DR GeneTree; ENSGT00940000155517; -.
DR HOGENOM; CLU_036910_1_1_1; -.
DR OrthoDB; 3795301at2759; -.
DR TreeFam; TF319780; -.
DR Proteomes; UP000002277; Chromosome 14.
DR Bgee; ENSPTRG00000006340; Expressed in fibroblast and 21 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13185; FERM_C_FRMD1_FRMD6; 1.
DR CDD; cd17198; FERM_F1_FRMD6; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR041781; FRMD6-FERM_C.
DR InterPro; IPR047145; FRMD6-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13429; FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY; 1.
DR PANTHER; PTHR13429:SF11; FERM DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 16..320
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 356..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 614 AA; 71010 MW; 7B54EECC7F33D191 CRC64;
MNKLNFHNNR VMQDRRSVCI FLPNDESLNI IINVKILCHQ LLVQVCDLLR LKDCHLFGLS
VIQNNEHVYM ELSQKLYKYC PKEWKKEASK GIDQFGPPMI IHFRVQYYVE NGRLISDRAA
RYYYYWHLRK QVLHSQCVLR EEAYFLLAAF ALQADLGNFK RNKHYGKYFE PEAYFPSWVV
SKRGKDYILK HIPNMHKDQF ALTASEAHLK YIKEAVRLDD VAVHYYRLYK DKREIEASLT
LGLTMRGIQI FQNLDEEKQL LYDFPWTNVG KLVFVGKKFE ILPDGLPSAR KLIYYTGCPM
RSRHLLQLLS NSHRLYMNLQ PVLRHIRKLE ENEEKKQYRE SYISDNLDLD MDQLEKRSRA
SGSSVGSMKH KRLSRHSTAS HSSSHTSGIE ADTKPRDTGP EDSYSSSAIH RKLKTCSSMT
SHGSSHTSGV ESGGKDRLEE DLQDDEIEML VDDPRDLEQM NEESLEVSPD MCIYITEDML
MSRKLNGHSG LIVKEIGSST SSSSETVVKL RGQSTDSLPQ TICRKPKTST DRHSLSLDDI
RLYQKDFLRI AGLCQDTAQS YTFGCGHELD EEGLYCNSCL AQQCINIQDA FPVKRTSKYF
SLDLTHDEVP EFVV
//
