ID H2Q8M0_PANTR Unreviewed; 592 AA.
AC H2Q8M0; A0A2J8PJU2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Prospero homeobox 2 {ECO:0000313|Ensembl:ENSPTRP00000011107.5};
GN Name=PROX2 {ECO:0000313|Ensembl:ENSPTRP00000011107.5,
GN ECO:0000313|VGNC:VGNC:3351};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000011107.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000011107.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000011107.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AACZ04008418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2Q8M0; -.
DR STRING; 9598.ENSPTRP00000011107; -.
DR PaxDb; 9598-ENSPTRP00000011107; -.
DR Ensembl; ENSPTRT00000011998.5; ENSPTRP00000011107.5; ENSPTRG00000006542.5.
DR VGNC; VGNC:3351; PROX2.
DR eggNOG; KOG3779; Eukaryota.
DR GeneTree; ENSGT00940000154790; -.
DR HOGENOM; CLU_016051_1_0_1; -.
DR InParanoid; H2Q8M0; -.
DR OMA; HIQENQI; -.
DR TreeFam; TF316638; -.
DR Proteomes; UP000002277; Chromosome 14.
DR Bgee; ENSPTRG00000006542; Expressed in Brodmann (1909) area 10 and 19 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.500; Homeo-prospero domain; 1.
DR InterPro; IPR023082; Homeo_prospero_dom.
DR InterPro; IPR037131; Homeo_prospero_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR039350; Prospero_homeodomain.
DR PANTHER; PTHR12198; HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26; 1.
DR PANTHER; PTHR12198:SF5; PROSPERO HOMEOBOX PROTEIN 2; 1.
DR Pfam; PF05044; HPD; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51818; HOMEO_PROSPERO; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 437..592
FT /note="Prospero"
FT /evidence="ECO:0000259|PROSITE:PS51818"
FT REGION 21..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 592 AA; 65537 MW; E9B425D7A8421BD0 CRC64;
MDPNSILLSP QPQICSHLAE ACTEGERSSS HPELDRDSPF PWSQVPSSSP TDPEWFGDEH
IQAKRARVET IVRGMCLSPN PLVPGNAQAG VSPRCPKKAR ERKRKQNLPT QQGLLMPAPA
WDQGNRKGGP RVREQLHLLK QQLRHLQEHI LQAAKPRDTA QGPGGCGTGK GPLSAKQGNG
CGPHSWVVDG DHQQGTSKDL SGAEKHQESE KPSFLPSGAP ASLEILRKEL TRAVSQAVDS
VLQKVLLDPP GRLTQLGRSF QGQVPEGRNE PSPPVGGACK DPLALVALPR RVQLQAGVPV
GNLSLAKRLD SPRYLIPPRM IPKPCQDPPA NCPLTAPSHI QENQILSQLL GHGCNNGHWS
SSPPQDSSSQ RHPSSEPALR PWRTTKPQPL VLSQQQCPLP FTSAHLESLP LLPSVKMEQR
GLHAVTEALP FSLVHIQEGL NPGHLKKAKL MFFFTRYPSS NLLKVYFPDV QFNRCITSQM
IKWFSNFREF YYIQMEKSAR QAISDGVTNP KMLVVLRNSE LFRALNMHYN KGNDFEVPDC
FLEIASLTLQ EFFRAVSAGR DSDPSWKKPI YKIISKLDSD IPEIFKSSSY PQ
//
