ID H2Q8R6_PANTR Unreviewed; 1970 AA.
AC H2Q8R6; A0A2J8PKR0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=EMAP like 5 {ECO:0000313|Ensembl:ENSPTRP00000011247.6};
GN Name=EML5 {ECO:0000313|Ensembl:ENSPTRP00000011247.6,
GN ECO:0000313|VGNC:VGNC:3434};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000011247.6, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000011247.6, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000011247.6}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04008327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016782032.1; XM_016926543.1.
DR Ensembl; ENSPTRT00000012142.6; ENSPTRP00000011247.6; ENSPTRG00000006609.6.
DR GeneID; 453093; -.
DR CTD; 161436; -.
DR VGNC; VGNC:3434; EML5.
DR eggNOG; KOG2106; Eukaryota.
DR GeneTree; ENSGT00940000156613; -.
DR HOGENOM; CLU_001930_0_0_1; -.
DR OrthoDB; 2959353at2759; -.
DR TreeFam; TF317832; -.
DR Proteomes; UP000002277; Chromosome 14.
DR Bgee; ENSPTRG00000006609; Expressed in pituitary gland and 19 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF16; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 5; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 2.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 11.
DR SMART; SM00320; WD40; 28.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 4..48
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 250..264
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 330..362
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 381..460
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT DOMAIN 663..715
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 900..930
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1235..1267
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1345..1403
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1698..1732
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1742..1822
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REGION 609..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1275..1298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1327..1356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1970 AA; 219511 MW; FBFE2320FEF9CF2A CRC64;
MAARSAPSCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYSPR EHRQKFYRGH
SDDIISLALH PERVLVATGQ VGKEPYICIW DSYTVQTISV LKDVHTHGIA CLAFDLDGQR
LVSVGLDSKN AVCVWDWKRG KMLSMAPGHT DRIFDISWDL YQPNKLVSCG VKHIKFWSLC
GNALTPKRGV FGKTGDLQTI LCLACARDEL TYSGALNGDI YVWKGINLIR TIQGAHAAGI
FSMNACEEGF ATGGRDGCIR LWDLTFKPIT VIDLRETDQG YKGLSVRSVC WRGDHILVGT
QDSEIFEIVV QERNKPFLIM QGHCEGELWA LAVHPTKPLA VTGSDDRSVR IWSLVDHALI
ARCNMEEPIR CAAVNADGIH LALGMKDGSF TVLRVRDMTE VVHIKDRKEA IHELKYSPDG
TYLAVGCNDS SVDIYGVAQR YKKVGECLGS LSFITHLDWS SDSRYLQTND GNGKRLFYRM
PGGKEVTSTE EIKGVHWASW TCVSGLEVNG IWPKYSDIND INSVDGNYIG QVLVTADDYG
IIKLFRYPCL RKGAKFRKYI GHSAHVTNVR WSHDYQWVIS IGGADHSVFQ WKFIPERKLK
DAVHIAPQES LADSHSDESD SDLSDVPELD SEIEQETQLT YRRQVYKEDL PQLKEQCKEK
QKSATSKRRE RAPGNSIRLH FVHGYRGYDC RSNLFYTQIG EIVYHVAAVG VIYNRQQNTQ
RFYLGHDDDI LCLTIHPLKD YVATGQVGRD PSIHIWDTET IKPLSILKGG HHQYGVSAVD
FSADGKRLAS VGIDDSHTVV LWDWKKGEKL SIARGSKDKI FVVKMNPYVP DKLITAGIKH
MKFWRKAGGG LIGRKGYIGT LGKNDTMMCA VYGWTEEMAF SGTSTGDVCI WRDIFLVKTV
KAHDGPVFSM HALEKGFVTG GKDGIVALWD DSFERCLKTY AIKRAALAPG SKGLLLEDNP
SIRAISLGHG HILVGTKNGE ILEVDKSGPI TLLVQGHMEG EVWGLATHPY LPICATVSDD
KTLRIWDLSP SHCMLAVRKL KKGGRCCCFS PDGKALAVGL NDGSFLMANA DTLEDLVSFH
HRKDMISDIR FSPGSGKYLA VASHDSFIDI YNVMNSKRVG ICKGATSYIT HIDWDIRGKL
LQVNTGAKEQ LFFEAPRGKK QTIPSVEVEK IAWASWTSVL GLCCEGIWPV IGEVTDVTAS
CLTSDKMVLA TGDDLGFVKL FRYPTKGKFG KFKRYVAHST HVTNVRWTYD DSMLVTLGGT
DMSLMVWTNE MEGYREKRPC DSEESDIDSE EDGGYDSDVT RENEISYTIR ALSTNIRPML
GIKPHLQQKE PSIDERPPVS RAPPQPEKLQ TNNVGKKKRP IEDLVLELIF GYRGRDCRNN
VHYLNDGDDI IYHTASVGIL HNVATGSQSF YQEHNDDILC LTVNQHPKFI NIVATGQVGD
SADMSATAPS IHIWDAMNKQ TLSILRCYHS KGVCSVSFSA TGKLLLSVGL DPEHTITIWR
WQEGAKIASR AGHNQRIFVA EFRPDSDTQF VSVGVKHVKF WTLAGRALLS KKGLLSTLED
ARMQTMLAIA FGANNLTFTG TISGDVCVWK DHILCRIVAR AHNGPVFAMY TTLRDGLIVT
GGKERPSKEG GAVKLWDQEL RRCRAFRLET GQATDCVRSV CRGKGKILVG TRNAEIIEVG
EKNAACNILV NGHVDGPIWG LATHPSRDFF LSAAEDGTVR LWDIADKKML NKVNLGHAAR
TVCYSPEGDM VAIGMKNGEF IILLVSSLKI WGKKRDRRCA IHDIRFSPDS RYLAVGSSEN
SVDFYDLTLG PTLNRISYCK DIPSFVIQMD FSADSSYLQV SSGCYKRHVY EVPSGKHLMD
HAAIDRITWA TWTSILGDEV LGIWSRHAEK ADVNCACVSH SGISLVTGDD FGMVKLFDFP
CPEKFAKHKR FLGHSPHVTN IRFTSGDRHV VSAGGDDCSL FVWKCVHTPH
//
