ID H2Q8V7_PANTR Unreviewed; 970 AA.
AC H2Q8V7; A0A2J8QMD4; K7DLC8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Chromosome 14 open reading frame 49 {ECO:0000313|EMBL:JAA43264.1};
DE SubName: Full=Spectrin repeat containing nuclear envelope family member 3 {ECO:0000313|Ensembl:ENSPTRP00000011407.4};
GN Name=SYNE3 {ECO:0000313|EMBL:JAA43264.1,
GN ECO:0000313|Ensembl:ENSPTRP00000011407.4,
GN ECO:0000313|VGNC:VGNC:57266};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000011407.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000011407.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA43264.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA43264.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000011407.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR EMBL; AACZ04029262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABE01001475; JAA43264.1; -; mRNA.
DR Ensembl; ENSPTRT00000012320.4; ENSPTRP00000011407.4; ENSPTRG00000006691.4.
DR VGNC; VGNC:57266; SYNE3.
DR eggNOG; ENOG502QQSI; Eukaryota.
DR GeneTree; ENSGT00440000039367; -.
DR HOGENOM; CLU_012764_0_0_1; -.
DR OMA; ACCLEDQ; -.
DR TreeFam; TF331132; -.
DR Proteomes; UP000002277; Chromosome 14.
DR Bgee; ENSPTRG00000006691; Expressed in lymph node and 20 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR Gene3D; 1.20.58.60; -; 3.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR47535; MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G; 1.
DR PANTHER; PTHR47535:SF2; NESPRIN-3; 1.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 1.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS51049; KASH; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TOPO_DOM 1..920
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TRANSMEM 921..939
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 942..970
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 912..970
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT COILED 198..225
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 295..357
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 970 AA; 111502 MW; 80C98AC902FA227D CRC64;
MTQQPQEDFD RSMEDAQAWM KAVQDQLQVN DNTQGPRAAL EARLWETEKI CQLEPEGRVK
VDLVLRMAEA LLACCPGDQK PGILARLKDI KAQWEETVTY MTHCHSRIEW VWLHWSEYLL
ARDEFYRWFQ KMMVTLEPHI ELQLGLKEKQ WQLSHAQVLL HNVDNQAVLL DRLLEEAASL
FNRIGDPSVD EDAQKRMKAE YDAVKAKAQE RVDLLEQVAR EHEEYQAGVD EFQLWLKAVV
EKVNGCLGRN CKLPITQRLS TLQDIAKDFP RGEESLERLE EQSVGVIRNT SPLGAEKITG
ELEEMRKVLE KLRALWEEEE ERLRGLLQSR GACEQQIKQL EAELSEFRMV LQRLAQEGLQ
PAGKAGTEDE LVAHWRRYSA TRAALASEEP RLDWLQAQLK ELIVFPHNLK PLSDSVIAAI
QEYQSLKVKS ARLCNAAGVE LWQHFQRPLQ DLQLWKALAQ RLLEVTASLP DLPSLHTFLP
QIEAALMESS RLKELLTMLQ LKKDLLIGIF GQERATALLE QVAGSMRDRD LLHNGLLQRK
SKLQSLLAQH KDFGAAFEPL QRKLLDLQVR VQAEKGLQRD LPGKQAQLST LQGLQEEGLD
LGAQMEAARP LVQENPNHQH KMDQLSSDFQ ALQRSLEDLV DRCRQSVQEH CTFSHQLLEL
RQWIVVTTQK LEAHRGEAGP GDAESQEAEF ERLVAEFPEK ETQLSLVEAQ GWLVMEKSSP
EGAAVVQEEL RELAESWRAL RLLEESLLSL IRNWHLQRMA VDSGKKMVFT NNIPKSGFLI
NPMDPIPRHR RREEEGSHED FSQLLRNFGQ WLQVENSKLV RIIAMRTSTA EDLRTRKSKL
QELEARVPEG QHLFENLLRL GPARGTSDEL EDLRYQWMLY KSKLKDSGHL LTQSSPGEPT
GFQKTRRWRG LGSLFRRVCC VALPLQLLLL LFLLLLFLLP VREEDRSCTL ANNFARSFTL
MLRYNGPPPT
//
