ID H2Q976_PANTR Unreviewed; 195 AA.
AC H2Q976; A0A2J8QDR8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Calcineurin B homologous protein 1 {ECO:0000256|ARBA:ARBA00041033};
DE AltName: Full=Calcineurin B-like protein {ECO:0000256|ARBA:ARBA00041827};
DE AltName: Full=Calcium-binding protein CHP {ECO:0000256|ARBA:ARBA00041595};
DE AltName: Full=Calcium-binding protein p22 {ECO:0000256|ARBA:ARBA00042678};
DE AltName: Full=EF-hand calcium-binding domain-containing protein p22 {ECO:0000256|ARBA:ARBA00042749};
GN Name=CHP1 {ECO:0000313|EMBL:JAA05086.1,
GN ECO:0000313|Ensembl:ENSPTRP00000011844.4, ECO:0000313|VGNC:VGNC:7203};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000011844.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000011844.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA05086.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA05086.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA38380.1}, Skin {ECO:0000313|EMBL:JAA26543.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA17273.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000011844.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Endomembrane
CC system {ECO:0000256|ARBA:ARBA00004308}. Endoplasmic reticulum-Golgi
CC intermediate compartment {ECO:0000256|ARBA:ARBA00004399}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the calcineurin regulatory subunit family. CHP
CC subfamily. {ECO:0000256|ARBA:ARBA00038164}.
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DR EMBL; AACZ04038071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01006252; JAA05086.1; -; mRNA.
DR EMBL; GABC01006251; JAA05087.1; -; mRNA.
DR EMBL; GABF01004872; JAA17273.1; -; mRNA.
DR EMBL; GABD01006557; JAA26543.1; -; mRNA.
DR EMBL; GABD01006556; JAA26544.1; -; mRNA.
DR EMBL; GABE01006359; JAA38380.1; -; mRNA.
DR EMBL; GABE01006358; JAA38381.1; -; mRNA.
DR EMBL; GABE01006357; JAA38382.1; -; mRNA.
DR RefSeq; XP_523056.2; XM_523056.6.
DR STRING; 9598.ENSPTRP00000011844; -.
DR PaxDb; 9598-ENSPTRP00000011844; -.
DR Ensembl; ENSPTRT00000012795.5; ENSPTRP00000011844.4; ENSPTRG00000006942.5.
DR GeneID; 467662; -.
DR KEGG; ptr:467662; -.
DR CTD; 11261; -.
DR VGNC; VGNC:7203; CHP1.
DR eggNOG; KOG0034; Eukaryota.
DR GeneTree; ENSGT00940000154629; -.
DR HOGENOM; CLU_061288_10_5_1; -.
DR OMA; FRQFMRT; -.
DR OrthoDB; 339700at2759; -.
DR TreeFam; TF354284; -.
DR Proteomes; UP000002277; Chromosome 15.
DR Bgee; ENSPTRG00000006942; Expressed in liver and 21 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR GO; GO:0042308; P:negative regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:0071073; P:positive regulation of phospholipid biosynthetic process; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0051453; P:regulation of intracellular pH; IEA:Ensembl.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR46002:SF1; CALCINEURIN B HOMOLOGOUS PROTEIN 1; 1.
DR PANTHER; PTHR46002; EG:114D9.1 PROTEIN-RELATED; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein kinase inhibitor {ECO:0000256|ARBA:ARBA00023013};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 26..61
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 110..145
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 151..186
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 195 AA; 22456 MW; 8E82EEF0CA5E832F CRC64;
MGSRASTLLR DEELEEIKKE TGFSHSQITR LYSRFTSLDK GENGTLSRED FQRIPELAIN
PLGDRIINAF FPEGEDQVNF RGFMRTLAHF RPIEDNEKSK DVNGPEPLNS RSNKLHFAFR
LYDLDKDEKI SRDELLQVLR MMVGVNISDE QLGSIADRTI QEADQDGDSA ISFTEFVKVL
EKVDVEQKMS IRFLH
//
