ID H2Q9P5_PANTR Unreviewed; 1180 AA.
AC H2Q9P5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Integrin subunit alpha 11 {ECO:0000313|Ensembl:ENSPTRP00000012347.5};
GN Name=ITGA11 {ECO:0000313|Ensembl:ENSPTRP00000012347.5,
GN ECO:0000313|VGNC:VGNC:3542};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000012347.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000012347.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000012347.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AACZ04064638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2Q9P5; -.
DR Ensembl; ENSPTRT00000013324.5; ENSPTRP00000012347.5; ENSPTRG00000007215.5.
DR VGNC; VGNC:3542; ITGA11.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000155465; -.
DR HOGENOM; CLU_004111_2_1_1; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000002277; Chromosome 15.
DR Bgee; ENSPTRG00000007215; Expressed in fibroblast and 12 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF21; INTEGRIN ALPHA-11; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 6.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1134..1158
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 16..77
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 83..143
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 156..337
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 347..398
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 454..519
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 520..578
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 582..642
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1180 AA; 132673 MW; 5BC61681DAE817A7 CRC64;
MEHRKGSLGW FTDTFNMDTR KPRVIPGSRT AFFGYTVQQH DISGNKWLVV GAPLETNGYQ
KTGDVYKCPV IHGNCTKLNL GRVTLSNVSE RKDNMRLGLS LATNPKDNSF LACSPLWSHE
CGSSYYTTGM CSRVNSNFRF SKTVAPALQR CQTYMDIVIV LDGSNSIYPW VEVQHFLINI
LKKFYIGPGQ IQVGVVQYGE DVVHEFHLND YRSVKDVVEA ASHIEQRGGT ETRTAFGIEF
ARSEAFQKGG RKGAKKVMIV ITDGESHDSP DLEKVIQQSE RDNVTRYAVA VLGYYNRRGI
NPETFLNEIK YIASDPDDKH FFNVTDEAAL KDIVDALGDR IFSLEGTNKN ETSFGLEMSQ
TGFSSHVVED GVLLGAVGAY DWNGAVLKET SAGKVIPLRE SYLKEFPEEL KNHGAYLGYT
VTSVVSSRQG RVYVAGAPRF NHTGKVILFT MHNNRSLTIH QALRGQQIGS YFGSEITSVD
IDGDGVTDVL LVGAPMYFNE GRERGKVYVY ELRQNRFVYD GTLKDSHSYQ NARFGSSIAS
VRDLNQDSYN DVVVGAPLED NHAGAIYIFH GFRGSVLKTP KQRITASELA TGLQYFGCSI
HGQLDLNEDG LIDLAVGALG NAVILWSRPV VQINASLHFE PSKINIFHRD CKRSGRDATC
LAAFLCFTPV FLAPHFQTTT VGIRYNATMD ERRYTPRAHL DEGGDRFTNR AVLLSSGQEL
CERINFHVLD TADYVKPVTF SVEYSLEDPD HGPMLDDGWP TTLRVSVPFW NGCNEDEHCV
PDLVLDARSD LPTAMEYCQR VLRKPVQDCS AYTLSFDTTV FIVESTRRRV AVEATLENRG
ENAYSTVLNI SQSANLQFAS LIQKEDSDGS IECVNEERRL QKKVCNVSYP FFRAKAKVAF
RLDFEFSKSI FLHHLEIELA AGSDSNERDS TKEDNVAPLR FHLKYEADVL FTRSSSLSHY
EVKPNSSLER YDGIGPPFSC IFRIQNLGLF PIHGMMMKIT IPIATRSGNR LLKLRDFLTD
QANTSCNIWG NSTEYRPTPV EEDLRRAPQL NHSNSDVVSI NCNIRLVPNQ EINFHLLGNL
WLRSLKALKY KSMKIMVSAA LQRQFHSPFI FREEDPSRQI VFEISKQEDW QVPIWIIVGS
TLGGLLLLAL LVLALWKLGF FKSARRRREP GLDPTPKVLE
//