ID H2QAA3_PANTR Unreviewed; 837 AA.
AC H2QAA3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Telomere length regulation protein TEL2 homolog {ECO:0000256|ARBA:ARBA00018231};
GN Name=TELO2 {ECO:0000313|Ensembl:ENSPTRP00000012982.3,
GN ECO:0000313|VGNC:VGNC:13795};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000012982.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000012982.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000012982.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TEL2 family.
CC {ECO:0000256|ARBA:ARBA00006133}.
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DR EMBL; AACZ04061597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04061598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016784658.1; XM_016929169.1.
DR AlphaFoldDB; H2QAA3; -.
DR Ensembl; ENSPTRT00000014013.3; ENSPTRP00000012982.3; ENSPTRG00000007596.4.
DR GeneID; 453818; -.
DR KEGG; ptr:453818; -.
DR CTD; 9894; -.
DR VGNC; VGNC:13795; TELO2.
DR eggNOG; KOG4346; Eukaryota.
DR GeneTree; ENSGT00390000006698; -.
DR HOGENOM; CLU_008764_1_0_1; -.
DR InParanoid; H2QAA3; -.
DR OMA; YDKKRHG; -.
DR OrthoDB; 8746at2759; -.
DR TreeFam; TF313925; -.
DR Proteomes; UP000002277; Chromosome 16.
DR Bgee; ENSPTRG00000007596; Expressed in cerebellar cortex and 19 other cell types or tissues.
DR GO; GO:0070209; C:ASTRA complex; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0110078; C:TTT Hsp90 cochaperone complex; IEA:Ensembl.
DR GO; GO:0051879; F:Hsp90 protein binding; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0050821; P:protein stabilization; IBA:GO_Central.
DR GO; GO:0007004; P:telomere maintenance via telomerase; IBA:GO_Central.
DR Gene3D; 1.25.40.720; Telomere length regulation protein 2, C-terminal domain; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038528; TEL2_C_sf.
DR InterPro; IPR019337; Telomere_length_regulation_dom.
DR PANTHER; PTHR15830; TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER; 1.
DR PANTHER; PTHR15830:SF10; TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG; 1.
DR Pfam; PF10193; Telomere_reg-2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 512..620
FT /note="Telomere length regulation protein conserved"
FT /evidence="ECO:0000259|Pfam:PF10193"
FT REGION 444..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 91718 MW; 9C93BFEF25D605B6 CRC64;
MEPAPSGVRL AVREAIHALS SSEDGGHIFC TLESLKRYLG EMEPPALPRE KEEFASVHFS
PVLRCLASRL SPAWLELLPD GRLEELWASF FLEGPADQAF LVLMETIEGA AGPSFRLMKM
ARLLARFLRE GRLAVLMEAQ CRQQTQPGFI LLRETLLGKV VALPDHLGNR LQQENLAEFF
PQNYFRLLGD EVVRVLQAVV DSLQGGLDSS VSFVSQVLGK ACVHGRQQEI LGVLVPRLAA
LTQGSYLHQR VCWRLVEHVP DRAMEAVLTG LVEAAPGPEV LSRLLGNLVV KNKKAQFVMT
RKLLFLQSRL TTPMLQSLLG HLAMDSQRRP LLLQVLKELL ETWGSSSAIR HTPLPQQRHV
SKAVLICLAH LGEPELRDSR DELLASMMAG VKCRLDSSLP PVRRLGMIVA EVVSARIHPE
GPPLKFQYEE DELSLELLAL ASPQPAGDGA SEAGTSLVPA TAEPPAETPA EIVDGGVPQA
QLAGSDSDLD SDDEFVPYDM SGDRELKSSK APAYVRDCVE ALTTSEDIER WEAALRALEG
LVYRSPTATR EVSVELAKVL LHLEEKTCVV GFAGLRQRAL VAVTVTDPAP VADYLTSQFY
ALNYSLRQRM DILDVLTLAA QELSRPGCLG RTPQPGSPSP NTPCLPEAAV SQPGSAVASD
WRVVVEERIR SKTRRLSKGG PRQGPAGSPS RFSSVAGHFF FPLLQRFDRP LVTFDLLGED
QLVLGRLAHT LGALMCLAVN TTVAVAMGKA LLEFVWALRF HVDAYVRQGL LSAISSVLLS
VPAARLLEDL MDELLEARSW LADVAEKDPD EDCRTLALRA LLLLQRLKNR LFPPASP
//