ID H2QB24_PANTR Unreviewed; 896 AA.
AC H2QB24; A0A2J8MX41;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=NEDD4-binding protein 1 {ECO:0000256|ARBA:ARBA00039336};
GN Name=N4BP1 {ECO:0000313|EMBL:JAA07486.1,
GN ECO:0000313|Ensembl:ENSPTRP00000013822.3,
GN ECO:0000313|VGNC:VGNC:13743};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000013822.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000013822.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA07486.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA07486.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA42551.1}, Skin {ECO:0000313|EMBL:JAA31278.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA18031.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000013822.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC {ECO:0000256|ARBA:ARBA00004322}. Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the N4BP1 family.
CC {ECO:0000256|ARBA:ARBA00038274}.
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DR EMBL; AACZ04030040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01003852; JAA07486.1; -; mRNA.
DR EMBL; GABF01004114; JAA18031.1; -; mRNA.
DR EMBL; GABD01001822; JAA31278.1; -; mRNA.
DR EMBL; GABE01002188; JAA42551.1; -; mRNA.
DR RefSeq; XP_520627.3; XM_520627.5.
DR STRING; 9598.ENSPTRP00000013822; -.
DR PaxDb; 9598-ENSPTRP00000013822; -.
DR Ensembl; ENSPTRT00000014928.4; ENSPTRP00000013822.3; ENSPTRG00000008096.4.
DR GeneID; 465156; -.
DR CTD; 9683; -.
DR VGNC; VGNC:13743; N4BP1.
DR eggNOG; KOG3777; Eukaryota.
DR GeneTree; ENSGT00940000158682; -.
DR HOGENOM; CLU_014137_1_0_1; -.
DR OMA; ICHKRRS; -.
DR OrthoDB; 180910at2759; -.
DR TreeFam; TF315783; -.
DR Proteomes; UP000002277; Chromosome 16.
DR Bgee; ENSPTRG00000008096; Expressed in hindlimb stylopod muscle and 20 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016605; C:PML body; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IEA:Ensembl.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
DR GO; GO:0001818; P:negative regulation of cytokine production; IEA:Ensembl.
DR GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0031397; P:negative regulation of protein ubiquitination; IBA:GO_Central.
DR GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Ensembl.
DR GO; GO:0045088; P:regulation of innate immune response; IEA:Ensembl.
DR CDD; cd22476; KH-I_N4BP1; 1.
DR CDD; cd09032; KH-I_N4BP1_like_rpt1; 1.
DR CDD; cd18728; PIN_N4BP1-like; 1.
DR Gene3D; 3.40.50.11980; -; 1.
DR InterPro; IPR021869; RNase_Zc3h12_NYN.
DR PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR PANTHER; PTHR12876:SF26; NEDD4-BINDING PROTEIN 1; 1.
DR Pfam; PF11977; RNase_Zc3h12a; 1.
PE 2: Evidence at transcript level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 617..769
FT /note="RNase NYN"
FT /evidence="ECO:0000259|Pfam:PF11977"
FT REGION 403..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 100483 MW; 48A6843C8726B893 CRC64;
MAARAVLDEF TAPAEKAELL EQSRGRIEGL FGVSLAVLGA LGAEEPLPAR IWLQLCGAQE
AVHSAKEYIK GICEPELEER ECYPKDMHCI FVGAESLFLK SLIQDTCADL CILDIGLLGI
RGSAEAVVMA RSHIQQFVKL FENKENLPSS QKESEVKREF KQFVEAHADN YTMDLLILPT
SLKKELLTLT QGEENLFETG DDEVIEMRDS QQTEFTQNAA TGLNISRDET VLQEEARNKA
GTPVSELTKQ MDTVLSSSPD VLFDPINGLT PDEEALSNER ICQKRRFSDS EERHTKKQFS
LENVQEGEIL HDAKTLAGNV IADLSDSSTD SENLSPDIKE TTEEMEYNIL VNFFKTMGYS
QEIVEKVIKV YGPSTEPLLL LEEIEKENKR FQEDREFSAG TVYPETNKTK NKGVYSSTNE
LTTDSTPKKT QAHTQQNMVE KFSQLPFKVE AKPCTSNCRI NTFRTVPIEQ KHEVWGSNQN
YICNTDPETD GLSPSVASPS PKEVNFVSRG ASSHQPRVPL FPENGLHQQP EPLLPNNMKS
ACEKRLGCCS SPHSKPNCST LSPPMPLPQL LPSVTDARSA GPSDHIDSSV TGVQRFRDTL
KIPYKLELKN EPGRTDLKHI VIDGSNVAIT HGLKKFFSCR GIAIAVEYFW KLGNRNITVF
VPQWRTRRDP NVTEQHFLTQ LQELGILSLT PARMVFGERI ASHDDRFLLH LADKTGGIIV
TNDNFREFVN ESVSWREIIT KRLLQYTFVG DIFMVPDDPL GRSGPRLEEF LQKEVCLRDM
QPLLSVLPNV GMFDPSFRVP GTQAASTSHQ PPTRIQGAPS SHWLPQQPRF PLLPALPNLQ
QNLPMPAQRS SAETNELREA LLKIFPDSEQ RLKIDQILVA HPYMKDLNAL SAMVLD
//
