ID   H2QCX4_PANTR            Unreviewed;       494 AA.
AC   H2QCX4; A0A2J8KGH9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Keratin 12 {ECO:0000313|Ensembl:ENSPTRP00000015568.3};
GN   Name=KRT12 {ECO:0000313|Ensembl:ENSPTRP00000015568.3,
GN   ECO:0000313|VGNC:VGNC:12351};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000015568.3, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000015568.3, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000015568.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; AACZ04038951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_001168468.1; XM_001168468.4.
DR   AlphaFoldDB; H2QCX4; -.
DR   STRING; 9598.ENSPTRP00000015568; -.
DR   PaxDb; 9598-ENSPTRP00000015568; -.
DR   Ensembl; ENSPTRT00000016823.4; ENSPTRP00000015568.3; ENSPTRG00000009134.4.
DR   GeneID; 468241; -.
DR   KEGG; ptr:468241; -.
DR   CTD; 3859; -.
DR   VGNC; VGNC:12351; KRT12.
DR   eggNOG; ENOG502QTM6; Eukaryota.
DR   GeneTree; ENSGT00940000159382; -.
DR   HOGENOM; CLU_012560_8_3_1; -.
DR   InParanoid; H2QCX4; -.
DR   OMA; EHQNADH; -.
DR   OrthoDB; 4640531at2759; -.
DR   TreeFam; TF332742; -.
DR   Proteomes; UP000002277; Chromosome 17.
DR   Bgee; ENSPTRG00000009134; Expressed in cortex of kidney and 4 other cell types or tissues.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0061303; P:cornea development in camera-type eye; IEA:Ensembl.
DR   GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:0002009; P:morphogenesis of an epithelium; IBA:GO_Central.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR   PANTHER; PTHR23239:SF369; KERATIN, TYPE I CYTOSKELETAL 12; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN          125..440
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   COILED          129..163
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          232..266
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          338..432
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   494 AA;  53588 MW;  BEA4F5AB988922F0 CRC64;
     MDLSNNTMSL SVRTPGLSRR LSSQSVIGRP RGMSASSVGS GYGGSAFGFG TSCGGGFSAA
     SMFGSSSGFG GGSGSSMAGG LGACYGRALG GGSFGGLGMG FGGSPGGGSL GILSGNDGGL
     LSGSEKETMQ NLNDRLASYL DKVRALEEAN TELENKIREW YETRGTGTAD ASQSDYSKYY
     PLIEDLRNKI ISASIGNAQL LLQIDNARLA AEDFRMKYEN ELALRQGVEA DINGLRRVLD
     ELTLTRTDLE MQIESLNEEL AYMKKNHEDE LQSFRVGGPG EVSVEMDAAP GVDLTRLLND
     MRAQYETIAE QNRKDAEAWF IEKSGELRKE ISTNTEQLQS SKSEVTDLRR AFQNLEIELQ
     SQLAMKKSLE DSLAEAEGDY CAQLSQVQQL ISNLEAQLLQ VRADAERQNV DHQRLLNVKA
     RLELEIETYR RLLDGEAQGD GLEESLFVTD SKSQAQSTDS SKDPTKTRKI KTVVQEMVNG
     EVVSSQVQEI EELM
//