ID H2QD48_PANTR Unreviewed; 262 AA.
AC H2QD48; A0A2J8KFA2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Transmembrane protein 106A {ECO:0000313|EMBL:JAA02286.1, ECO:0000313|Ensembl:ENSPTRP00000065078.1};
GN Name=TMEM106A {ECO:0000313|EMBL:JAA02286.1,
GN ECO:0000313|Ensembl:ENSPTRP00000065078.1,
GN ECO:0000313|VGNC:VGNC:14202};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000065078.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000065078.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA02286.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA02286.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA33918.1}, Skin {ECO:0000313|EMBL:JAA30259.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA18978.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000065078.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TMEM106 family.
CC {ECO:0000256|ARBA:ARBA00008111}.
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DR EMBL; AACZ04038980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01009052; JAA02286.1; -; mRNA.
DR EMBL; GABF01003167; JAA18978.1; -; mRNA.
DR EMBL; GABD01002841; JAA30259.1; -; mRNA.
DR EMBL; GABE01010821; JAA33918.1; -; mRNA.
DR RefSeq; XP_009430390.1; XM_009432115.2.
DR RefSeq; XP_016787225.1; XM_016931736.1.
DR RefSeq; XP_016787226.1; XM_016931737.1.
DR RefSeq; XP_016787227.1; XM_016931738.1.
DR STRING; 9598.ENSPTRP00000065078; -.
DR PaxDb; 9598-ENSPTRP00000015732; -.
DR Ensembl; ENSPTRT00000106589.1; ENSPTRP00000065078.1; ENSPTRG00000009242.6.
DR GeneID; 468267; -.
DR KEGG; ptr:468267; -.
DR CTD; 113277; -.
DR VGNC; VGNC:14202; TMEM106A.
DR eggNOG; ENOG502RY0I; Eukaryota.
DR GeneTree; ENSGT00940000161546; -.
DR OrthoDB; 5353335at2759; -.
DR TreeFam; TF328907; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000009242; Expressed in adult mammalian kidney and 21 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0035780; P:CD80 biosynthetic process; IEA:Ensembl.
DR GO; GO:0035781; P:CD86 biosynthetic process; IEA:Ensembl.
DR GO; GO:0042116; P:macrophage activation; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl.
DR GO; GO:1904407; P:positive regulation of nitric oxide metabolic process; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR Gene3D; 6.20.20.10; -; 1.
DR InterPro; IPR009790; TMEM106.
DR InterPro; IPR048509; TMEM106_C.
DR InterPro; IPR048511; TMEM106_N.
DR PANTHER; PTHR28556:SF3; TRANSMEMBRANE PROTEIN 106A; 1.
DR PANTHER; PTHR28556; TRANSMEMBRANE PROTEIN 106B; 1.
DR Pfam; PF07092; TMEM106; 1.
DR Pfam; PF21002; TMEM106_N; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 94..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..93
FT /note="Transmembrane protein 106 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21002"
FT DOMAIN 116..252
FT /note="Transmembrane protein 106 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07092"
SQ SEQUENCE 262 AA; 28908 MW; 6F4ACECFC36D991A CRC64;
MGKTFSQLGS WREDENKSIL SSKPAIGSKA VSYSSTGSSK SFCSCVPCEG TADASFVTCP
TCQGSGKIPQ ELEKQLVALI PYGDQRLKPK HTKLFVFLAV LICLVTSSFI VFFLFPRSVI
VQPAGLNSST VAFDEADIYL NITNILNISN GNYYPIMVTQ LTLEVLHQSL VVGQVSNNLL
LHIGPLASEQ MFYAVATKIR DENTYKICTW LEIKVHHVLL HIQGTLTCSY LSHSEQLVFQ
SYEYVDCRGN ASVPHQLTPH PP
//
