ID   H2QDJ1_PANTR            Unreviewed;       598 AA.
AC   H2QDJ1; A0A2J8MF51;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=Heat shock transcription factor 5 {ECO:0000313|Ensembl:ENSPTRP00000016053.4};
GN   Name=HSF5 {ECO:0000313|Ensembl:ENSPTRP00000016053.4,
GN   ECO:0000313|VGNC:VGNC:9328};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000016053.4, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000016053.4, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000016053.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|ARBA:ARBA00006403,
CC       ECO:0000256|RuleBase:RU004020}.
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DR   EMBL; AACZ04026972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_511908.2; XM_511908.6.
DR   AlphaFoldDB; H2QDJ1; -.
DR   STRING; 9598.ENSPTRP00000016053; -.
DR   PaxDb; 9598-ENSPTRP00000016053; -.
DR   Ensembl; ENSPTRT00000017338.5; ENSPTRP00000016053.4; ENSPTRG00000009453.6.
DR   GeneID; 455156; -.
DR   CTD; 124535; -.
DR   VGNC; VGNC:9328; HSF5.
DR   eggNOG; KOG1508; Eukaryota.
DR   GeneTree; ENSGT00510000048674; -.
DR   HOGENOM; CLU_037490_1_0_1; -.
DR   InParanoid; H2QDJ1; -.
DR   OMA; HRIWQNS; -.
DR   OrthoDB; 2908279at2759; -.
DR   TreeFam; TF330401; -.
DR   Proteomes; UP000002277; Chromosome 17.
DR   Bgee; ENSPTRG00000009453; Expressed in testis.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000232; HSF_DNA-bd.
DR   InterPro; IPR027725; HSF_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10015:SF278; HEAT SHOCK FACTOR PROTEIN 5; 1.
DR   PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF00447; HSF_DNA-bind; 1.
DR   SMART; SM00415; HSF; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN          10..130
FT                   /note="HSF-type DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM00415"
FT   REGION          163..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          202..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          543..578
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..184
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..216
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   598 AA;  65342 MW;  F255F3B92147C19F CRC64;
     MEALLSTPIN PNNFPAKLWR LVNSPRYRSI RWDGRGEGLL IDQPLFEAEL LSPPGPGGGG
     GTAGAGAEPE LFKTTSFTSF IRQLNLYGFR KVVLGGPGGG KPAGNGPLHH FHNPHFRRDQ
     PQLLVHLKRL TSANKAKLAA GLEVPCRPPN RFQRLLITSA SASAAAAPLQ HQQPPPPAGP
     RPEPQGPVAV GQFHRSFRRD SLSPYSCVST PSHDHSTYPL KGLDRTPVPH RIWQNSLGMH
     PGQVETSPTF SDKGVPFAVL QRFPTEVTYT LQPSTTSVHV QQGPQTMVSS SQKYSNYTPS
     AQYSQAYYPT AVLQCCSPTH MDALSSCVTP TASSYAHCNY FQNPSMQSSY PVEFLPSNWP
     CSTTDENTKT EVNLEAVFQI VDELHSSPKL EMVKVEPVEN QCPTSPSYRG QHILANSNNS
     NPCSASQASQ LEPLTPVGSD IMSFVVGTEQ AVASSLPQSP EYIYTIHTAQ PVENSTIQES
     AAIQQAHVKL KEHLNHNPSP SSVVFVQEGP PFSTHQVDAN IKCQTSSREN ILPSEQMGFL
     ISEMGPASKP SEDTGLATPA RYREHRSNSQ QGKSPDLHLL VDVACKQERF PKEEELKE
//