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Database: UniProt
Entry: H2QDN9_PANTR
LinkDB: H2QDN9_PANTR
Original site: H2QDN9_PANTR 
ID   H2QDN9_PANTR            Unreviewed;      1836 AA.
AC   H2QDN9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   20-JUN-2018, entry version 47.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN4A {ECO:0000313|Ensembl:ENSPTRP00000016195,
GN   ECO:0000313|VGNC:VGNC:12667};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000016195, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000016195, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000016195}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AACZ04070143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016788230.1; XM_016932741.1.
DR   RefSeq; XP_016788231.1; XM_016932742.1.
DR   STRING; 9598.ENSPTRP00000016195; -.
DR   PaxDb; H2QDN9; -.
DR   Ensembl; ENSPTRT00000017486; ENSPTRP00000016195; ENSPTRG00000009532.
DR   GeneID; 100612017; -.
DR   KEGG; ptr:100612017; -.
DR   CTD; 6329; -.
DR   VGNC; VGNC:12667; SCN4A.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H2QDN9; -.
DR   KO; K04837; -.
DR   OMA; GNDTWYG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000002277; Chromosome 17.
DR   Bgee; ENSPTRG00000009532; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008052; Na_channel_a4su_mammal.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01665; NACHANNEL4.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    150       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    195    214       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    226    247       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    423    451       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    579    597       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    609    632       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    644    668       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    689    717       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    776    802       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1032   1050       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1071   1093       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1099   1119       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1148   1174       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1272   1295       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1354   1372       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1384   1402       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1414   1434       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1471   1499       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1572   1598       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    456       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      580    806       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      816   1026       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1030   1304       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1353   1608       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       25     45       {ECO:0000256|SAM:Coils}.
FT   COILED      461    488       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1836 AA;  208070 MW;  9399014059CC0083 CRC64;
     MARPSLCTLV PLGPECLRPF TRESLAAIEQ RAVEEEARLQ RNKQMEIEEP ERKPRSDLEA
     GKNLPMIYGD PPPEVIGIPL EDLDPYYSNK KTFIVLNKGK AIFRFSATPA LYLLSPFSVV
     RRGAIKVLIH ALFSMFIMIT ILTNCVFMTM SDPPPWSKNV EYTFTGIYTF ESLIKILARG
     FCVDDFTFLR DPWNWLDFSV IMMAYLTEFV DLGNISALRT FRVLRALKTI TVIPGLKTIV
     GALIQSVKKL SDVMILTVFC LSVFALVGLQ LFMGNLRQKC VRWPPLFNDT NTTWYSNDTW
     YGNDTWYGNE MWYDNDSWYA NDTWNSHASW ATNDTFDWDA YISDEGNFYF LEGSNDALLC
     GNSSDAGHCP EGYECIKTGR NPNYGYTSYD TFSWAFLALF RLMTQDYWEN LFQLTLRAAG
     KTYMIFFVVI IFLGSFYLIN LILAVVAMAY AEQNEATLAE DKEKEEEFQQ MLEKFKKHQE
     ELEKAKAAQA LEGGEADGDP AHGKDCNGSL DTSQGEKGAP RQSGSGDSGI SDAMEELEEA
     HQKCPPWWYK CAHKVLIWNC CAPWLKFKNI IHLIVMDPFV DLGITICIVL NTLFMAMEHY
     PMTEHFDNVL TVGNLVFTGI FTAEMVLKLI AMDPYEYFQQ GWNIFDSIIV TLSLVELGLA
     NVQGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII VFIFAVVGMQ
     LFGKSYKECV CKIALDCNLP RWHMHDFFHS FLIVFRILCG EWIETMWDCM EVAGQAMCLT
     VFLMVMVIGN LVVLNLFLAL LLSSFSADSL AASDEDGEMN NLQIAIGRIK LGIGFAKAFL
     LGLLHGKILS PKDIMLSLGE ADGAGEAGEA GETAPEDEKK EPPEEDLKKD NHILNHMGLA
     DGPPSSLELD HLNFINNPYL TIQVPIASEE SDLEMPTEEE TDTLSEPEDS KKPPQPLYDG
     NSSVCSTADY KPPEEDPEEQ AEENPEGEQP EECFTEACVQ RWPCLYVDIS QGRGKKWWTL
     RRACFKIVEH NWFETFIVFM ILLSSGALAF EDIYIEQRRV IRTILEYADK VFTYIFIMEM
     LLKWVAYGFK VYFTNAWCWL DFLIVDVSII SLVANWLGYS ELGPIKSLRT LRALRPLRAL
     SRFEGMRVVV NALLGAIPSI MNVLLVCLIF WLIFSIMGVN LFAGKFYYCI NTTTSERFDI
     SEVNNKSECE SLMHTGQVRW LNVKVNYDNV GLGYLSLLQV ATFKGWMDIM YAAVDSREKE
     EQPQYEVNLY MYLYFVIFII FGSFFTLNLF IGVIIDNFNQ QKKKLGGKDI FMTEEQKKYY
     NAMKKLGSKK PQKPIPRPQN KIQGMVYDLV TKQAFDITIM ILICLNMVTM MVETDDQSQL
     KVDILYNINM IFIIIFTGEC VLKMLALRQY YFTVGWNIFD FVVVILSIVG LALSDLIQKY
     FVSPTLFRVI RLARIGRVLR LIRGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYSIFG
     MSNFAYVKKE SGIDDMFNFE TFGNSIICLF EITTSAGWDG LLNPILNSGP PDCDPNLENP
     GTSVKGDCGN PSIGICFFCS YIIISFLIVV NMYIAIILEN FNVATEESSE PLGEDDFEMF
     YETWEKFDPD ATQFIAYSRL SDFVDTLQEP LRIAKPNKIK LITLDLPMVP GDKIHCLDIL
     FALTKEVLGD SGEMDALKQT MEEKFMAANP SKVSYEPITT TLKRKHEEVC AIKIQRAYRR
     HLLQRSVKQA SYMYRHSHDG SGDDAPEKEG LLANTMSKMY GHENGNSSSP SPEEKGEAGD
     TGPTMGLMPI SPSDTAWPPA PPPGQTVRPG VKESLV
//
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